Effects of Acetylsalicylic Acid on the Gastric Mucosa and the Possible Ameliorative Role of Silymarin in Adult Albino Rat | ||||
| Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry | ||||
| Volume 16, Issue 1, June 2024, Page 27-40 PDF (1.74 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsd.2024.336980 | ||||
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| Authors | ||||
Reneah R. Bushra ; Ashraf E. Bastwrous
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| Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University. | ||||
| Abstract | ||||
| Background: Aspirin or acetylsalicylic acid (ASA) is among the most popular used drugs in the world. Gastric lesions are one of aspirin's often-occurring side effects. Silymarin is a natural compound that exhibits effects against inflammation, oxidation, and apoptosis. Aim of the work: This study was conducted to evaluate ASA-induced gastric mucosal damage and the potential ameliorative role of silymarin. Material and Methods: Thirty adult male albino rats were randomly divided into three equal groups: a control group (subdivided into a negative control group without any medication and a positive control group that received distilled water/day orally by gastric gavage for 2 weeks), ASA-treated group (received 200 mg ASA/kg b.w./day orally for 2 weeks), and ASA+silymarin-treated group (received 200 mg ASA/kg b.w./day in addition to 50 mg silymarin/kg b.w./day, orally for 2 weeks). At the end of the experiment, the rats were anaesthetized and sacrificed. The stomach was removed, opened, and processed for histological and iNOS immunohistochemical evaluation. Area % of collagen fibres and iNOS immune expression and gastric mucosal thickness of all animal groups were measured and compared. Results: The ASA induced gastric mucosal histological changes in the form of erosion, degeneration, vacuolization of cells, and dilatation of blood capillaries. The area % of collagen fibres and iNOS was significantly increased and gastric mucosal thickness was significantly decreased in ASA-treated groups in comparison to the control. These changes were improved in the ASA+silymarin-treated group. Conclusion: ASA induced gastric mucosal injuries and the concomitant administration of silymarin could ameliorate these effects. | ||||
| Keywords | ||||
| Gastric mucosa; ASA; Silymarin; Rat | ||||
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