Study the effect of Cu(II) on the biological efficiency of pyrimidine derivatives in the presence of 1,10-phenanthroline and 2,2\-bipyridin | ||||
Bulletin of Faculty of Science, Zagazig University | ||||
Article 2, Volume 2023, Issue 4, January 2024, Page 15-34 PDF (2.19 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfszu.2023.194650.1252 | ||||
View on SCiNiTO | ||||
Authors | ||||
Heba Kamal 1; sadeek atia sadeek2; hassan El‐Sayed3; mohamed El-Attar4 | ||||
1faculty of science zagazig university chemistry department | ||||
2chemistry dep. | ||||
3Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt | ||||
4chemistry dep | ||||
Abstract | ||||
The cupper(II) complexes [Cu(L1)(Bipy)(H2O)2]Cl2.2.5H2O (1), [Cu(L2)(Phen)(H2O)2]Cl2.2.5H2O (2) and [Cu(L3)(Phen)(H2O)2]Cl2.0.5H2O (3) (L1=1-[4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]ethanone, L2=4-Oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, L3=Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2- methyl-4H-pyran-3-carboxylate, Bipy=2,2\-bipyridine, Phen=1,10-phenanthroline) were done. Elemental analysis, magnetic moment, molar conductance, thermal analysis, infrared spectra, and electronic spectrum investigations were used to describe these complexes. The molar conductance results of complexes indicated that the cupper complexes are electrolyte with 1:2. The FT-IR data showed that L1, L2, L3, Phen, Bipy coordinated with metal ions as bidentate ligands. The magnetic moment of Cu(II) complexes found around (1.71 BM) which indicate the structure of complexes as octahedral geometry. The postulated stereochemistry and subsequently the predicted mechanism of heat degradation were validated by TG and DTG studies. The Horowitz-Metzger (HM) and Coats-Redfern (CR) techniques were used to compute the activation thermodynamic parameters. Thermal decomposition processes of complexes (1), (2) and (3) are non-spontaneous (negative values for ΔS*). In vitro antibacterial properties of the mixed ligand and their complexes were evaluated against several bacterial and fungi strains. | ||||
Keywords | ||||
Phen and Bipy copper pyrimidine derivative complexes; XRD; thermal analyses; antimicrobial investigation | ||||
Statistics Article View: 74 PDF Download: 99 |
||||