Advances in Understanding and Treating Multiple Sclerosis: A Comprehensive Review

Mohamed, Eman; yasser, Fatma; Hagag, hagar; wageeh, juli; Khaled, Marc; Ashraf, Mohamed; Yahia, Norhan; Gamal, Omnia; Fahmy, Mohamed Ibrahim

doi:10.21608/jpsdm.2024.257173.1006

	Advances in Understanding and Treating Multiple Sclerosis: A Comprehensive Review
Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology
Volume 1, Issue 1 - Serial Number 10124, January 2024, Page 21-30 PDF (499.09 K)
Document Type: Review Articles.
DOI: 10.21608/jpsdm.2024.257173.1006
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Authors
Eman Mohamed¹; Fatma yasser¹; hagar Hagag¹; juli wageeh¹; Marc Khaled¹; Mohamed Ashraf¹; Norhan Yahia¹; Omnia Gamal¹; Mohamed Ibrahim Fahmy ²
¹Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt
²Department pf Pharmacology and Toxicology, faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), 12585, Giza, Egypt
Abstract
Introduction: Multiple sclerosis (MS) is an autoimmune disease resulting in neurodegeneration accompanied by chronic inflammatory response, apoptosis and neuronal loss. It is characterized by number of signs including paresthesia, spastic paralysis, cognitive impairment, and functional deficits. More than 2 million people worldwide suffering from the disease. The generation and development of MS are heterogeneous and manifold. Aim and concept of review: The aim of this review is to provide detailed information about the pathophysiology, different treatments and protective agents as well animal models used for studying multiple sclerosis in pharmacological experiments. Furthermore, the review sheds light on the molecular mechanisms involved in the pathogenesis of the disease including infiltration of immune cells and expression of inflammatory and oxidative biomarkers that represent a significant indication of the disease. Conclusion: The review concluded with the potential therapeutic and neuroprotective approaches of management of multiple sclerosis. It provides future perspective concerning with controlling the incidence of multiple sclerosis.
Keywords
Multiple sclerosis; inflammatory; apoptosis; neurodegeneration


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