Syntheses of New Antimicrobial Cellulose Materials Based 2-((2-aminoethyl)amino)-4-aryl-6-indolylnicotinonitriles | ||||
| Egyptian Journal of Chemistry | ||||
| Article 10, Volume 60, Issue 3, June 2017, Page 465-477 PDF (4.3 MB) | ||||
| DOI: 10.21608/ejchem.2017.3375 | ||||
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| Abstract | ||||
| 2-((2-aminoethyl)amino)-4-aryl-6-indolylnicotinonitriles (1a-c), were grafted into two different cellulosic intermediates, where 6-deoxy tosyl cellulose that was prepared by the reaction of microcrystalline cellulose (MCC) with tosyl chloride in DMA/LiCl. Additionally, the dialdehyde carboxymethyl cellulose (2,3-DACMC) obtained by regioselective periodate oxidation of carboxymethyl cellulose (CMC) were also condensed with the same amine compounds (1a-c) via Schiff’s base reaction aiming to obtain new functionalized amino cellulosic derivatives with predictable applications. The products were characterized by FT-IR, 13C-NMR, elemental analysis, SEM, and X-ray diffraction. The antimicrobial activity of the new cellulose amine derivatives and Schiff’s bases of (2,3-DACMC) were assayed on four different microorganisms. Among the tested compounds, (3a) and (3b) proved to be promising antimicrobial cellulosic material that could be used as a broad spectrum wound healing gels or manufacturing of packaging materials. | ||||
| Keywords | ||||
| Heterocyclic amino compounds; 6-deoxycellulose tosylate; Schiff`s base; CMC; Periodate oxidation; antimicrobial activity | ||||
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