The efficacy of pregabalin on the duration of the spinal anesthesia and the early postoperative pain after total knee arthroplasty | ||||
| Ain-Shams Journal of Anesthesiology | ||||
| Volume 16, Issue 1, 2024, Page 1-7 PDF (322.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asja.2024.250437.1009 | ||||
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| Authors | ||||
Tamer Samir Abdelsalam Abdelaziz   ; wael Abdelmoneim Mohamed Abdelwahab ; Ismail Mohammed Ibrahim
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| Department of Anesthesia & Intensive Care, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: The pain after knee surgery is a great challenge to physicians where lack of adequate analgesia causes many complications. Pregabalin, a gamma amino-butyric acid, has shown analgesic and sedative effects. Therefore, this article examines the effect of a preoperative single dose of oral pregabalin on total knee arthroplasty pain after surgery. Results: The study results showed that pregabalin was found to prolong the spinal block duration (2-segment regression, L2 regression, and Bromage2 regression time). pregabalin had no significant effect on the sensory nor motor block onset (P =1.000) (P =0.078) respectively. Pain score at 6hrs and 24hrs was significantly reduced in pregabalin group. In addition, frequency and total narcotic requirements were significantly reduced in pregabalin group. Conclusion: Premedication with oral pregabalin 150 mg promoted intrathecal bupivacaine efficacy, improved postoperative analgesia, and reduced narcotic requirements. | ||||
| Keywords | ||||
| Postoperative pain; pregabalin; spinal anesthesia; total knee arthroplasty | ||||
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