Egyptian “Ful Medames” Mitigates Metabolic Syndrome-Associated Inflammation through Regulation of Resistin, Leptin and Adipokine mRNA Expression in Wistar Rats | ||||
Egyptian Journal of Chemistry | ||||
Volume 67, Issue 13, December 2024, Page 403-420 PDF (973.05 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2024.257739.9044 | ||||
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Authors | ||||
Maha Hanafy Mahmoud ![]() ![]() ![]() ![]() ![]() ![]() | ||||
1Nutrition & Food Science Dept., Institute of Food Industries & Nutrition Research, National Research Centre, Dokki, Cairo, P.O. 12622, Egypt. | ||||
2Environmental and Occupational Medicine department, National Research Centre, Dokki, Cairo, P.O. 12622, Egypt. | ||||
3Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. | ||||
4Food Technology Department, Institute of Food Industries & Nutrition Research, National Research Centre, Dokki, Cairo, P.O. 12622, Egypt. | ||||
Abstract | ||||
Metabolic syndrome is among the serious global health problems and is usually associated with inflammation. Dietary aspects contribution and genetic associations to minimize metabolic syndrome disorders and inflammation is a controversy point. The present study aims to evaluate the ability of the most popular Egyptian meals “Ful-Medames” to mitigate the metabolic syndrome associated disorders and inflammation in Wistar rats and its impact on the expression regulation of the white adipose tissue mediators; resistin, leptin and adiponectin. Three groups of male albino rats were used; negative, positive with induced metabolic syndrome and Ful-Medames fed group pre-induced for metabolic syndrome lasting for four weeks. Results revealed a high protein content of 26.56% for Ful-Medames, considerable antioxidant activity and polyphenolic compounds as detected by HPLC. Biochemical findings revealed restoring of the changed levels of blood glucose, total cholesterol, triglycerides, HDL-C, LDL-C, transaminases’ activity, insulin resistance, CRP and hepatosomatic index with marked improvement of changes in histopathological and resistin, leptin and adiponectin expression for the Ful-Medames fed metabolic syndrome group. Thus, it can be concluded that “Ful-Medames” counteracts metabolic syndrome-associated disorders and inflammation through restoring the disordered expression regulation of resistin, leptin and adiponectin. | ||||
Keywords | ||||
Metabolic syndrome; inflammation; Ful Medames; resistin; leptin; adiponectin | ||||
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