ELUSIVE PHARMACEUTICAL FUNCTION OF MULTI-ADVANTAGES DRUG DELIVERY SYSTEM FROM NATURAL MUSHROOM
Mohamed, M., El-Deeb, N., El-Assar, M., Farag, M., Ahmed, A. (2018). ELUSIVE PHARMACEUTICAL FUNCTION OF MULTI-ADVANTAGES DRUG DELIVERY SYSTEM FROM NATURAL MUSHROOM. EKB Journal Management System, 29(Issue 2-C), 19-25. doi: 10.21608/absb.2018.33808
Mahmoud A. Mohamed; Nehal M. El-Deeb; Mohamed R. El-Assar; Mohamed M. Farag; Ayman F. Ahmed. "ELUSIVE PHARMACEUTICAL FUNCTION OF MULTI-ADVANTAGES DRUG DELIVERY SYSTEM FROM NATURAL MUSHROOM". EKB Journal Management System, 29, Issue 2-C, 2018, 19-25. doi: 10.21608/absb.2018.33808
Mohamed, M., El-Deeb, N., El-Assar, M., Farag, M., Ahmed, A. (2018). 'ELUSIVE PHARMACEUTICAL FUNCTION OF MULTI-ADVANTAGES DRUG DELIVERY SYSTEM FROM NATURAL MUSHROOM', EKB Journal Management System, 29(Issue 2-C), pp. 19-25. doi: 10.21608/absb.2018.33808
Mohamed, M., El-Deeb, N., El-Assar, M., Farag, M., Ahmed, A. ELUSIVE PHARMACEUTICAL FUNCTION OF MULTI-ADVANTAGES DRUG DELIVERY SYSTEM FROM NATURAL MUSHROOM. EKB Journal Management System, 2018; 29(Issue 2-C): 19-25. doi: 10.21608/absb.2018.33808

ELUSIVE PHARMACEUTICAL FUNCTION OF MULTI-ADVANTAGES DRUG DELIVERY SYSTEM FROM NATURAL MUSHROOM

Al-Azhar Bulletin of Science
Article 3, Volume 29, Issue 2-C, December 2018, Page 19-25  XML PDF (520.35 K)
Document Type: Original Article
DOI: 10.21608/absb.2018.33808
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Authors
Mahmoud A. Mohamed* 1; Nehal M. El-Deeb2; Mohamed R. El-Assar3; Mohamed M. Farag1; Ayman F. Ahmed4
1Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
2Biopharmaceutical Product Research Department, City of Scientific Research and Technological Applications(SRTA-City), New Borg El-Arab City 21934, Alexandria, Egypt
3Polymer Materials Research Department Advanced Technology and New Material Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City 21934, Alexandria, Egypt
4Professor of Microbiology and Director of Al-Azhar Center for Fermentation Biotechnology and Applied Microbiology, Faculty of Science, Al-Azhar University, Cairo, Egypt
Abstract
The κ-carrageenan/sodium alginate beads were prepared for drug delivery system. The presented study; describes the preparation of κ-carrageenan/sodium alginate beads and their feasibility as potential carriers for delivery of polysaccharide drugs was evaluated. Moreover, the pH sensitive behavior of beads was measured in simulated gastrointestinal tract condition. Furthermore, the hydrogel beads were loaded with polysaccharides extracted from naturalmushroom, and their release was monitored. This results showed that; the swelling ratio of beads indicated pH-dependent properties with maximum water absorbing at pH 7.4. Moreover, the highest amount of released polysaccharide was 27.2% at pH value 7.4 within 6 h. It was observed that the encapsulation of κ-carrageenan with sodium alginate reduced the premature release of drug in the stomach mimicked condition acidic pH and released the drug more specifically to the colon mimicked condition alkaline pH. Therefore, these results suggest that microcapsules could be further developed as effective drug delivery system with pH sensitive drug release ability.
Keywords
Drugdelivery; mushroom; Polysaccharide; κ-carrageenan/sodium alginate; Beads
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