Facile One-Pot Strategy for Radiocoplexation of [99mtc]-Nitrido-Nebracetam for Brain Imaging: Biological Evaluation, Optimized Chromatographic Separation and Labeling Conditions
Sanad, M., Farag, A., Hussain, O., Fuozy, A. (2024). Facile One-Pot Strategy for Radiocoplexation of [99mtc]-Nitrido-Nebracetam for Brain Imaging: Biological Evaluation, Optimized Chromatographic Separation and Labeling Conditions. EKB Journal Management System, 67(13), 471-480. doi: 10.21608/ejchem.2024.257759.9053
M. H. Sanad; A.B. Farag; Omaima A. Hussain; A.S.M. Fuozy. "Facile One-Pot Strategy for Radiocoplexation of [99mtc]-Nitrido-Nebracetam for Brain Imaging: Biological Evaluation, Optimized Chromatographic Separation and Labeling Conditions". EKB Journal Management System, 67, 13, 2024, 471-480. doi: 10.21608/ejchem.2024.257759.9053
Sanad, M., Farag, A., Hussain, O., Fuozy, A. (2024). 'Facile One-Pot Strategy for Radiocoplexation of [99mtc]-Nitrido-Nebracetam for Brain Imaging: Biological Evaluation, Optimized Chromatographic Separation and Labeling Conditions', EKB Journal Management System, 67(13), pp. 471-480. doi: 10.21608/ejchem.2024.257759.9053
Sanad, M., Farag, A., Hussain, O., Fuozy, A. Facile One-Pot Strategy for Radiocoplexation of [99mtc]-Nitrido-Nebracetam for Brain Imaging: Biological Evaluation, Optimized Chromatographic Separation and Labeling Conditions. EKB Journal Management System, 2024; 67(13): 471-480. doi: 10.21608/ejchem.2024.257759.9053

Facile One-Pot Strategy for Radiocoplexation of [99mtc]-Nitrido-Nebracetam for Brain Imaging: Biological Evaluation, Optimized Chromatographic Separation and Labeling Conditions

Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Page 471-480  XML PDF (451.13 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.257759.9053
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Authors
M. H. Sanadorcid 1; A.B. Farag2; Omaima A. Hussain3; A.S.M. Fuozy email orcid 3
1Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12578 Egypt
3Food Toxicology and Contaminants Department, National Research Centre, Dokki, Cairo, Egypt.
Abstract
Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are central to regulating excitatory synaptic transmission in the central nervous system (CNS) Therefore, the aim of this research is to study the biodistribution to demonstrate the concentration of [99 mTc]-nitrido-nebracetam in the target organ (brain) using healthy groups of Swiss albino mice. The radiotracer [99mTc]-nitrido-nebracetam ([99mTc]-N-Neb) complex was labelled using the core [99mTc≡N] 2+.Many factors have been studied to optimize high radiochemical yields (>97.5).Quality control studies were made perfectly. A process of biodistribution indicated that this complex, [99mTc]-N-tamsulosin, was washed out through the urinary pathway within 3 hours after injection. In addition, the brain uptake of this complex was 11.88% after 30 min post-injection as a novel probe for (AMPA) receptor targeting. Hence, the radiotracer of [99mTc]-N-Neb could be used as a radiotracer for brain imaging through the AMPA receptor.
Keywords
[99mTc]-nitrido-nebracetam; [99mTc]-nitrido core; biological evaluation; brain; imaging
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