PROTECTIVE AND THERAPEUTIC EFFECTS OF OLIVE OIL AND FICUSCARICA ON THEHISTOLOGICAL ANDCYTOLOGICAL INJURIESOF LIVER AND KIDNEY IN -IRRADIATED MALE ALBINO RATS | ||||
| Al-Azhar Bulletin of Science | ||||
| Article 14, Volume 29, Issue 2-C, December 2018, Page 69-88 PDF (3.36 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/absb.2018.33820 | ||||
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| Authors | ||||
| Ahmed A. Gafar* ; Mahmoud A. Khalifa; Fathy Elshaer | ||||
| Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| The present study was designed to determine the possible protective and therapeutic effects of olive oil and/or Ficus carica against radiation-induced cytological and histological changes in liver and Kidney of male albino rats. Irradiation was performed by whole-body exposure of rats to an acute single dose gamma radiation of 6 Gy. Irradiated rats received, via gavage, extra virgin olive oil (7.6 ml/kg b.wt), and/or extract of Ficus carica fruit (1 g/kg b.wt) before and/or after radiation exposure. Six rats were sacrificed on the 1st and 15th-day post-irradiation exposure at the control and treated irradiated subgroups. Time duration for this experiment was one month. The γ-Irradiation treated group revealedhisto pathological alterations in the hepatic and renal tissues on the 1st and 15th-day post-irradiation as compared to the control rats. The administration of the olive oil and/or Ficus carica showed beneficial results against the deleterious effects of γ-irradiation. A better ameliorative effect was noticed with the combined treatments that revealed the synergistic effect between them. In conclusion, the administration of the olive oil and/or Ficus carica provides considerable radioprotective and radiotherapeutic effects against whole body γ-radiation in male Wistar albino rats. | ||||
| Keywords | ||||
| olive oil; Ficus carica; γ-radiation; histology; cytology | ||||
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