Facile One-Pot Strategy For Radiopreprationof Radioiodinated Phenylpiracetam As A New Highly Selective Radiotracer For Brainimaging | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 189-198 PDF (365.97 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.257311.9017 | ||||
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| Authors | ||||
M. H. Sanad 1; A. B. Farag2; Gomaa N. Abdel-Rahman 3; Ahmed S. M. Fouzy  3
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| 1Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt | ||||
| 2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12578 Egypt | ||||
| 3Food Toxicology and Contaminants Department, National Research Centre, Dokki 12622, Cairo, Egypt | ||||
| Abstract | ||||
| The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizing agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO. | ||||
| Keywords | ||||
| Phenylpiracetam; I-131; Labeling; Brain imaging; Biodistribution studies | ||||
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