GERMLINE BREAST CANCER SUSCEPTIBILITY GENES MUTATION(BRCA) AND EXPRESSION OF PROGRAMMED DEATH LIGAND-1(PDL-1) IN TRIPLE-NEGATIVE BREAST CANCER EGYPTIAN PATIENTS AND CORRELATION WITH CLINICOPATHOLOGICAL CHARACTERISTICS | ||||
ALEXMED ePosters | ||||
Article 1, Volume 6, Issue 1, January 2024, Page 20-21 | ||||
Document Type: Preliminary preprint short reports of original research | ||||
DOI: 10.21608/alexpo.2024.264876.1776 | ||||
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Authors | ||||
Mohamed Farouk Mostafa Ismael1; Nashaat Saad Lotfy Shehata1; Azza Darwish2; Eman Sheta Ali Gawdat Elsawy3; Vandrome Nakundi Kakonga 1 | ||||
1Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University | ||||
2Department of clinical oncology and nuclear medicine, Faculty of Medicine, Alexandria University | ||||
3Department of Pathology, Faculty of Medicine, Alexandria University | ||||
Abstract | ||||
Triple-negative breast carcinoma (TNBC) is one of the subtypes of breast cancer, known to have a poor prognosis.The most common risk factor is the family history of breast carcinoma, with germline mutation on BRCA1/2 genes being frequently found in comparison to other subtypes. However, non-metastatic TNBC is highly heterogeneous; two subgroups of patients can be described: on the one hand, patients with high-risk disease, not achieving pathological complete response (pCR) despite intense neoadjuvant treatment, and on the other hand, a second group of patients with good prognosis, achieving pCR with less pre-surgery treatment. There is an ongoing effort to de-escalate and escalate therapy, tailoring treatment better to the patients who need it at the right time. AIM OF THE WORK: This study aimed to assess the germline BRCA 1/2 mutation and PD-L1 expression in patients with non-metastatic TNBC presented at the Alexandria Clinical Oncology department. It also sought the correlation of the above biomarkerswith the clinicopathological characteristics and the response to neoadjuvant chemotherapy. | ||||
Keywords | ||||
Triple-negative breast carcinoma (TNBC); GERMLINE BREAST CANCER SUSCEPTIBILITY GENES MUTATION(BRCA); PROGRAMMED DEATH LIGAND-1(PDL-1) | ||||
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