Valsartan ameliorated cognitive decline, oxidative stress and inflammation in AlCl3-induced Alzheimer's disease in rats

Saeed, Noha M.; Esmail, Manar M; Abdel-Rahman, Hanaa; Elgindy, Ali M

doi:10.21608/erurj.2024.221868.1053

	Valsartan ameliorated cognitive decline, oxidative stress and inflammation in AlCl3-induced Alzheimer's disease in rats
ERU Research Journal
Volume 3, Issue 2, April 2024, Page 1038-1057 PDF (928.99 K)
Document Type: Original Article
DOI: 10.21608/erurj.2024.221868.1053
View on SCiNiTO
Authors
Noha M. Saeed ¹; Manar M Esmail¹; Hanaa Abdel-Rahman²; Ali M Elgindy¹
¹Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt
²Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in cognitive and memory deficits. The objective of the study was to investigate the potential neuroprotective effects of valsartan against the neurobehavioral and pathological changes that occur in rats with AD induced by aluminum chloride (AlCl₃). The study involved eighteen male rats, which were divided into three groups: control, AD, and valsartan. The control group was given saline, the AD group was given AlCl₃ (70 mg/kg/day p.o.) for 28 days, and the valsartan group was given valsartan (30 mg/kg/day p.o.) for 28 days, one hour after the injection of AlCl₃.Behavioral tests, including open field, Morris water maze, and novel object tests were conducted and brain tissues were analyzed for biochemical and histological changes at the end of the experiment. Treatment with valsartan resulted in improvements in behavioral impairments caused by AlCl₃. Moreover, valsartan attenuated body weight, oxidative stress, neuroinflammation as well as histopathological alterations induced by AlCl₃. The study's findings suggest that valsartan may have potential neuroprotective effects against the development of AD induced by aluminum intoxication.
Keywords
Alzheimer’s disease; valsartan; aluminum chloride; oxidative stress; neuroinflammation


Statistics Article View: 149 PDF Download: 71