NOVEL POTENTIAL DRUG INTERACTIONS WITH BISOPROLOL IN HOSPITALIZED ACUTE CORONARY SYNDROME PATIENTS
Okda, S., Kassem, A., Mahmoud Elamrawy, A., Salahuddin, A., Elonsy, S., El-Bassiouny, N. (2024). NOVEL POTENTIAL DRUG INTERACTIONS WITH BISOPROLOL IN HOSPITALIZED ACUTE CORONARY SYNDROME PATIENTS. EKB Journal Management System, 47(1), 395-413. doi: 10.21608/bfsa.2024.247704.1962
Sherouk Okda; Amira B. Kassem; Ahmed Mahmoud Elamrawy; Ahmad Salahuddin; sohila M Elonsy; Noha El-Bassiouny. "NOVEL POTENTIAL DRUG INTERACTIONS WITH BISOPROLOL IN HOSPITALIZED ACUTE CORONARY SYNDROME PATIENTS". EKB Journal Management System, 47, 1, 2024, 395-413. doi: 10.21608/bfsa.2024.247704.1962
Okda, S., Kassem, A., Mahmoud Elamrawy, A., Salahuddin, A., Elonsy, S., El-Bassiouny, N. (2024). 'NOVEL POTENTIAL DRUG INTERACTIONS WITH BISOPROLOL IN HOSPITALIZED ACUTE CORONARY SYNDROME PATIENTS', EKB Journal Management System, 47(1), pp. 395-413. doi: 10.21608/bfsa.2024.247704.1962
Okda, S., Kassem, A., Mahmoud Elamrawy, A., Salahuddin, A., Elonsy, S., El-Bassiouny, N. NOVEL POTENTIAL DRUG INTERACTIONS WITH BISOPROLOL IN HOSPITALIZED ACUTE CORONARY SYNDROME PATIENTS. EKB Journal Management System, 2024; 47(1): 395-413. doi: 10.21608/bfsa.2024.247704.1962

NOVEL POTENTIAL DRUG INTERACTIONS WITH BISOPROLOL IN HOSPITALIZED ACUTE CORONARY SYNDROME PATIENTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 27, Volume 47, Issue 1, June 2024, Page 395-413  XML PDF (1.75 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2024.247704.1962
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Authors
Sherouk Okda1; Amira B. Kassem email 1; Ahmed Mahmoud Elamrawy2; Ahmad Salahuddinorcid 3; sohila M Elonsyorcid 4; Noha El-Bassiounyorcid 1
1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damanhour University, Egypt
2Cardiology Department, Faculty of Medicine, Alexandria university, Alexandria, Egypt
3Department of Biochemistry, Faculty of Pharmacy, Damanhour university, Damanhour, Egypt
4Department of Pharmaceutical Analytical Chemistry, Faculty of pharmacy, Damanhour University, Damanhour, Egypt
Abstract
Abstract

Objectives: Drug-drug interactions (DDI) pose a real challenge especially in patients with complicated therapeutic regimens such as acute coronary syndrome (ACS) patients. Cardiac patients are more vulnerable to potential drug-drug interactions (pDDI). This study aimed to assess DDIs involving Bisoprolol among other drugs in ACS patients.

Methods: This is an observational study including 128 hospitalized patients with ACS who were candidates for Bisoprolol therapy and received at least two medications. Bisoprolol peak concentration, heart rate and blood pressure of patients were assessed. Medications of patients were analyzed for potential drug interactions using Micromedex, Lexi Interact and Drugs.com databases. Assessment of actual drug interactions was also conducted.

Results: A total of 1039 pDDIs were detected and their severity was categorized into moderate (54.95%) and major (45.04%). Regarding the actual DDIs, 4 drug interactions involving Bisoprolol were identified: Amlodipine/Bisoprolol (2.3%), Empagliflozin/Bisoprolol (10.2%), Aspirin/Bisoprolol (96.9%) and Potassium Chloride/Bisoprolol (10.2%), while 6 drug interactions involving other drugs were observed including Empagliflozin/Spironolactone (7%), Levofloxacin/Insulin (4.7%), Furosemide/Insulin (3.9%), Clopidogrel/Fondaparinux (11.7%), Aspirin/Fondaparinux (13.3%) and Aspirin/Furosemide (8.59%).

Conclusions: This study highlighted novel drug interactions such as Amlodipine/Bisoprolol, Empagliflozin/Bisoprolol and Empagliflozin/Spironolactone interactions. The study also emphasized the possible beneficial role of these interactions in ACS patients, this warrants the need for intense monitoring of drug interactions in ACS patients for drug therapy optimization and avoidance of adverse drug reactions.
Keywords
Drug-Drug Interactions; Acute coronary syndrome; Bisoprolol; Polypharmacy
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