Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis
Abdelmoneim, S., Hafez, D., Aboelsaad, I., Hamdy, N., Elhadi, Y., El-ganainy, S., Deghidy, E., Nour El-Deen, A., Elrewany, E., Khalil, A., Salem, K., kabeel, S., Shaaban, R., Alnagar, A., Fadel, E., Elfeshawy, N., Tahoun, M., El-Khatib, Z., Ghazy, R. (2024). Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis. EKB Journal Management System, 1(1), 58-81. doi: 10.21608/japs.2024.249802.1003
Shaimaa Abdelaziz Abdelmoneim; Dina Mohamed Hanaa Hafez; Iman Ahmed Fathalla Aboelsaad; Noha Alaa Hamdy; Yasir Ahmed Mohammed Elhadi; Samar Ossama El-ganainy; Ehsan Akram Deghidy; Ahmed El-Sayed Nour El-Deen; Ehab Mohamed Adel Elrewany; Alaa Hamdy Taha Khalil; Karem Mohamed Salem; Samar Galal kabeel; Ramy Shaaban; Amr Alnagar; Eman Ahmad Fadel; Nagwa Ibrahim Elfeshawy; Mohamed Mostafa Tahoun; Ziad El-Khatib; Ramy Mohamed Ghazy. "Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis". EKB Journal Management System, 1, 1, 2024, 58-81. doi: 10.21608/japs.2024.249802.1003
Abdelmoneim, S., Hafez, D., Aboelsaad, I., Hamdy, N., Elhadi, Y., El-ganainy, S., Deghidy, E., Nour El-Deen, A., Elrewany, E., Khalil, A., Salem, K., kabeel, S., Shaaban, R., Alnagar, A., Fadel, E., Elfeshawy, N., Tahoun, M., El-Khatib, Z., Ghazy, R. (2024). 'Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis', EKB Journal Management System, 1(1), pp. 58-81. doi: 10.21608/japs.2024.249802.1003
Abdelmoneim, S., Hafez, D., Aboelsaad, I., Hamdy, N., Elhadi, Y., El-ganainy, S., Deghidy, E., Nour El-Deen, A., Elrewany, E., Khalil, A., Salem, K., kabeel, S., Shaaban, R., Alnagar, A., Fadel, E., Elfeshawy, N., Tahoun, M., El-Khatib, Z., Ghazy, R. Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis. EKB Journal Management System, 2024; 1(1): 58-81. doi: 10.21608/japs.2024.249802.1003

Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis

Journal of Advanced Pharmaceutical Sciences
Volume 1, Issue 1, January 2024, Page 58-81  XML PDF (781.27 K)
Document Type: Review Article
DOI: 10.21608/japs.2024.249802.1003
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Authors
Shaimaa Abdelaziz Abdelmoneimorcid 1; Dina Mohamed Hanaa Hafezorcid 2; Iman Ahmed Fathalla Aboelsaadorcid 3; Noha Alaa Hamdy email orcid 4; Yasir Ahmed Mohammed Elhadiorcid 5; Samar Ossama El-ganainyorcid 6; Ehsan Akram Deghidyorcid 7; Ahmed El-Sayed Nour El-Deenorcid 8; Ehab Mohamed Adel Elrewanyorcid 9; Alaa Hamdy Taha Khalilorcid 10; Karem Mohamed Salemorcid 11; Samar Galal kabeelorcid 12; Ramy Shaabanorcid 13; Amr Alnagarorcid 14; Eman Ahmad Fadelorcid 15; Nagwa Ibrahim Elfeshawyorcid 15; Mohamed Mostafa Tahounorcid 16; Ziad El-Khatiborcid 17; Ramy Mohamed Ghazyorcid 18
1Clinical Research Administration, Alexandria Directorate of Health Affairs, Egyptian Ministry of Health
2Pharmacy Department, Alexandria University Students Hospital, Epidemiology Specialist, Alexandria University, Egypt
3Department of Clinical Research, Maamora Chest Hospital , MoHP, Alexandria, Egypt
4Faculty of Pharmacy, Alexandria University,
5Department of Public Health, Medical Research office, Sudanese Medical Research Association, Khartoum, Sudan
6Department of Pharmacology & Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Egypt
7Biomedical Informatics and Medical Statistics Department , Medical Research Institute, Alexandria University, Egypt
8Physiology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt
9Tropical Health Department, High Institute of Public Health, Alexandria University
10Oncology Physician, Cairo University Medical School, Egypt
11Nephrology in Internal Medicine Department, Fayoum University, Egypt
12Clinical research department at Damietta Directorate for Health affairs, Ministry of Health and population, Egypt
13Department of Instructional Technology and Learning Sciences Utah State University, USA
14Department of general surgery, Faculty of Medicine, Alexandria University, Egypt
15Woman's Health and Midwifery Nursing, Faculty of Nursing, Mansoura University, Egypt
16Department of Epidemiology, High Institute of Public Health, Alexandria University
17Universite du Quebec en Abitibi-Temiscamingue (UQAT) , Quebec, Canada
18Tropical Health Department, High Institute of Public Health, Alexandria University, Egypt
Abstract
A challengeable obstacle to the introduction of new vaccine that affects the transmission of certain infections is vaccine hesitancy, despite the availability of vaccines.
To assess the theoretical tendencies and public attitudes concerning the COVID-19 vaccinations.
PsycINFO, Science Direct, Embase, Scopus, EBSCO, MEDLINEcentral/PubMed, ProQuest, SciELO, SAGE, Web of Science, and Google Scholar were searched. All papers detailing rejection and acceptance of the COVID-19 vaccine were included with no language restriction. Abstracts, proposals, conferences, editorials, author responses, reviews, case reports & series, books, and studies with data not accurately extracted or overlapping data were excluded. A meta-analysis was conducted using the random effect model of the pooled proportion of vaccine acceptance and rejection using the meta-package of R software. Egger’s regression test was performed to assess publication bias, and the quality of included studies was assessed using the Newcastle-Ottawa Scale.
Out of 12246 identified records, 36 articles were included in the quantitative analysis. The pooled proportion of COVID-19 vaccine rejection was 16% (95%CI:13-20, I2=100%), while that of COVID-19 vaccine acceptance was 65% (95% CI:60-70, I2=100%. Case-fatality ratio and geographical distribution represented the main determinants of vaccine acceptance. Vaccine acceptance increased by 27.17% (95% CI:3.46-50.88) for each 1% increase in case fatality (p<0.02). The acceptance increased in Africa by 1.86 (p=0.04) while the vaccine rejection decreased in Australia by 3.93(p<0.0001).
This meta-analysis demonstrated poor acceptance of COVID-19 vaccines, and the ratio of cases to fatalities had a profound effect on public perception of the vaccines. These findings should be used to inform relevant interventions for future pandemic responses.
PROSPERO registration-number:CRD42021232805
Keywords
COVID-19 vaccines; vaccine acceptance; vaccine hesitancy; vaccine rejection
Supplementary Files
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