Neuroprotective Effect of Cardamom Essential Oil Encapsulated Nanoparticles and Swimming in Aluminum Induced Alzheimer’s disease in Rats

Ashour, Magdi N.; Elias, Tahany R.; Rasheed, Wafaa I; El-Toukhya, Safinaz E; Youness, Eman R; Sleem, Amany A; Ramadan, Manal mohamed; Mahmoud, Khaled Fahmy; Yassen, Noha N.; Abdel-Monem, Mahmoud A; Aly, Omnia

doi:10.21608/ejchem.2024.251449.8997

	Neuroprotective Effect of Cardamom Essential Oil Encapsulated Nanoparticles and Swimming in Aluminum Induced Alzheimer’s disease in Rats
Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Page 37-52 PDF (745.53 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.251449.8997
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Authors
Magdi N. Ashour¹; Tahany R. Elias¹; Wafaa I Rasheed¹; Safinaz E El-Toukhya²; Eman R Youness¹; Amany A Sleem³; Manal mohamed Ramadan⁴; Khaled Fahmy Mahmoud ⁵; Noha N. Yassen⁶; Mahmoud A Abdel-Monem ¹; Omnia Aly ¹
¹Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.
²Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt
³Department of pharmacology, National Research Centre, Cairo, Egypt
⁴Department of Chemistry of Flavour and Aroma, National Research Centre, Cairo, Egypt.
⁵Food Technology Dep., National Research Centre, Dokki, Egypt
⁶Department of Pathology, National Research Centre, Cairo, Egypt.
Abstract
As there is currently no cure for Alzheimer's disease (AD), considerable research is required to create plans to block the processes that cause memory loss. Functionalized nanomedicines that are nanoparticles contain central core structures that guarantee the encapsulation to offer protection and longer blood circulation. The purpose of this study was to investigate the neuroprotective effects of swimming exercise and nanoparticle-encapsulated cardamom oil (NCEO) on aluminum chloride-induced oxidative damage in experimental rats used as models for Alzheimer's disease. Experimental rats were induced for AD then groups were divided into different treatment groups; dopenzil, NCEO and swimming training. Different biochemical and pathological parameters were evaluated in both serum and muscles. Results showed and improvement in the concerned parameters with different treatment strategies. It can be concluded that both swimming and NCEO can be advised for AD patients.
Keywords
Key words: Alzheimer’ s disease; swimming; nanoparticles encapsulated cardamom oil; Irisin; Aβ; PGC; 1α; FNDC5


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