Diagnostic Significance of Serum Cystatin C as A Predictor of Severity in COVID-19 Infected Egyptian Patients

Ashry, Walaa M. O.; Elzefzafy, Wafaa Mohammed; Abouzahab, Zakia; Abd El Raheem, Sabah Ebrahem; Mohamed, Eman El Sayed; Mohamed, Fatma Saffeyeldin; Edrees, Awatif Elmohamady; Abdulwehab, Mona Mohamed

doi:10.21608/ijma.2023.233684.1798

	Diagnostic Significance of Serum Cystatin C as A Predictor of Severity in COVID-19 Infected Egyptian Patients
International Journal of Medical Arts
Volume 5, Issue 12, December 2023, Page 3896-3905 PDF (1013.16 K)
Document Type: Original Article
DOI: 10.21608/ijma.2023.233684.1798
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Authors
Walaa M. O. Ashry ¹; Wafaa Mohammed Elzefzafy²; Zakia Abouzahab³; Sabah Ebrahem Abd El Raheem³; Eman El Sayed Mohamed³; Fatma Saffeyeldin Mohamed²^{, 4}; Awatif Elmohamady Edrees⁵^{, 4}; Mona Mohamed Abdulwehab³
¹Department of Medical Microbiology and Immunology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt
²Department of Hepato-gastroenterology and Infectious Diseases, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt
³Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt
⁴Department of Internal Medicine, College of Medicine, Taif University, Taif, Saudi Arabia
⁵Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
Abstract
Background: COVID-19 may produce a systemic inflammatory state and multiorgan dysfunction, including renal damage. Biochemical and radiological tests are important in assessing disease severity and selecting therapeutic options. Serum cystatin C [sCys C] is involved in immunomodulatory responses in inflammatory conditions and infections, and it reflects changes in borderline renal function. The Aim of the work: Measurement of serum cystatin C levels in COVID-19 infected Egyptian participants as a predictor of the disease`s severity. Patients and Methods: This was an observational case-control study carried out on 80 participants, including 60 Egyptian COVID-19 patients and 20 healthy individuals as controls. All participants were investigated for laboratory, medical, and radiological features of COVID-19 as well as serum cystatin C. Patients were distributed into three categories according to illness severity; each group involved 20 patients: mild cases [group I], moderate cases [group II], and severe cases [group III]. Results: Serum cystatin C levels were found to be higher in group III patients, with a highly statistically significant difference between groups. Group III patients had higher levels of CRP, D-dimer, serum urea, and creatinine, with a highly statistically significant difference between groups. With a cutoff of >9.6, there was a significant link between serum systatin C and the severity of COVID-19 disease, with 96.8% sensitivity and 100% specificity. Conclusion: The present study indicates that serum systatin C may serve as a tool for diagnosing potentially severe cases of COVID-19 infected Egyptian patients.
Keywords
COVID-19; Cystatin C; Acute phase response; Kidney injury


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