Lyophilized Growth Factors Foam in Chronic Ulcers | ||||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||||
| Articles in Press, Accepted Manuscript, Available Online from 01 February 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejprs.2024.263225.1330 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amr Mabrouk1; Hossam M Fahmy2; Mai Raafat Hammad   3; Adel Mabrouk1; Mohamed samir Badawy 4
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| 1Department of Plastic, Burn and Maxillofacial Surgery, Ain Shams University, Cairo, Egypt. | ||||
| 2Department of Laboratory and Transfusion medicine, Ain Shams University, Cairo, Egypt. | ||||
| 3Ain Shams University | ||||
| 4*Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Introduction Treatment of chronic ulcers involves addressing the underlying cause and interventions to improve the process of healing such as autologous platelet-rich plasma. Platelet-rich plasma has been extensively studied for its potential in promoting healing of chronic ulcers as it contains a high concentration of growth factors such as platelet derived growth factor, epithelial growth factor and fibroblast growth factor. Advanced growth factor delivery systems have been developed to prolong the bio-activity of growth factors. LGF have been developed by a patented method to overcome the discrepancies of conventional platelet rich plasma. In this study, we present LGFoam as a topical agent containing Lyophilized growth factors, for use in chronic lower limb ulcers for the purpose of improving healing. Methodology Comparison of ulcer size between LGFoam topically applied to non-healing lower limb ulcers of various etiologies, as opposed to conventional dressing with a 30-day follow up period. Conclusion Several advanced growth factors delivery systems have been developed for topical use. However, conflicting evidence exists for their efficacy, warranting further research. In our study, there was a statistically significant decrease in ulcer size for the LGFoam group, encouraging future studies into its use in promoting wound healing in general, especially chronic non-healing ulcers as a problematic entity. | ||||
| Keywords | ||||
| ulcer; chronic ulcer; growth factors; prp | ||||
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