The Full Motor Neurons Graft: A Preliminary Study in Rats | ||||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||||
| Articles in Press, Accepted Manuscript, Available Online from 05 February 2024 | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/ejprs.2024.263963.1332 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amr khater  1; Akihiko Takushima2
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| 1Mansoura University | ||||
| 2Kyorin university, Japan | ||||
| Abstract | ||||
| Introduction: conventional nerve grafting was used for treatment of nerve defects. However, the slow rate of nerve regeneration, donor site limitations and morbidities were considered the major disadvantages of this technique. In this article, a novel motor neuron nerve allografts were used to accelerate nerve regeneration and were compared to nerve allograft in a rat model. Methods: We harvested full motor neuron grafts and conventional nerve grafts and used them to reconstruct a ten mm defect in the motor nerve to the Extensor Digitorum communis (EDC). Results: Histological examination confirmed intact connections between the motor neurons and its axons. The mean of the amplitudes of evoked potentials of neuron graft group and conventional graft group were 12.2 +/- 3.6 milliampere and 8.0 +/- 6.0 milliampere. However, muscle force, muscle weight and histological examination showed insignificant differences between the two groups. Conclusion: full neuron transfer is a new type of nerve grafts in the rat model. As a preliminary report, we investigated the viability of the transferred nerve cells and if they worked as a booster for augmentation of the signals. Electrophysiological examinations showed favorable results and histological studies showed the survival of the motor neurons outside the central nervous system. | ||||
| Keywords | ||||
| neuron graft; nerve graft; Wallerian degeneration; nerve regeneration | ||||
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