The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin
Al-Al-kashef, A., Gaafar, A., Ibrahim, E., Nooman, M., El- Bana, M., Hussein, J. (2024). The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin. EKB Journal Management System, 67(13), 599-607. doi: 10.21608/ejchem.2024.258938.9104
Amr S. Al-Al-kashef; Alaa A. Gaafar; Eman A. Ibrahim; Mohamed U. Nooman; Mona A. El- Bana; Jihan Hussein. "The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin". EKB Journal Management System, 67, 13, 2024, 599-607. doi: 10.21608/ejchem.2024.258938.9104
Al-Al-kashef, A., Gaafar, A., Ibrahim, E., Nooman, M., El- Bana, M., Hussein, J. (2024). 'The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin', EKB Journal Management System, 67(13), pp. 599-607. doi: 10.21608/ejchem.2024.258938.9104
Al-Al-kashef, A., Gaafar, A., Ibrahim, E., Nooman, M., El- Bana, M., Hussein, J. The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin. EKB Journal Management System, 2024; 67(13): 599-607. doi: 10.21608/ejchem.2024.258938.9104

The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin

Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Page 599-607  XML PDF (447.91 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.258938.9104
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Authors
Amr S. Al-Al-kashef1; Alaa A. Gaafarorcid 2; Eman A. Ibrahim2; Mohamed U. Nooman1; Mona A. El- Bana3; Jihan Hussein email orcid 3
1Biochemistry Department, National Research Centre, Dokki, P.O,Giza 12622, Egypt.
2Plant Biochemistry Department, National Research Centre, Dokki,P.O, Giza 12622, Egypt.
3Medical Biochemistry Department, National Research Centre, Dokki, Giza, P.O. 12622 Egypt,
Abstract
Background: One of the most widely used insecticides, is alpha-cypermethrin (α-CYP). Excessive dependence on such insecticides leads to severe environmental pollution, negatively affecting human and animal health.

Aim: The goal of the current investigation based on utilizing Cyperus rotundus tuber non-polar extract, to assist reducing the deleterious impact of α-CYP on liver tissues of male albino rats.

Results: FT-IR analysis identified the most important active compounds present in the extract. While the active biochemical ones were confirmed by individualization and identification utilizing GC/MS. The results indicated that the most important active compounds in the hexane extract were oxygenated compounds,17-octadecynoic acid (60.51%) and 9-octadecenoic acid, methyl ester (6.54%) in addition to nitrogenated compounds, such as histidyl histidine (4.75 %). The results showed that the C. rotundus extract administration decreased liver enzymes; alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Also, it increased antioxidant; glutathione (GSH), superoxide dismutase (SOD) enzyme, decreased oxidant; malondialdehyde (MDA), and nitric oxide (NO). Furthermore, it decreased liver inflammatory markers; nuclear factor-κB (NF-κB), adiponectin, and lipocalin. Conclusion: Results indicated that C. rotundus hexane extract exerts a potent protective effect against α-CYP-induced oxidative damage and inflammation in rats’ liver tissues.
Keywords
Alpha-cypermethrin; Cyperus rotundus; Antioxidants; Fibrosis; Inflammation; Oxidative stress
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