Utilization of Acrylic Modified PET and Its Nanocomposite Fibers in Transdermal Medical Applications | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 379-385 PDF (383.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.257682.9041 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Shaymaa El-Sayed El-Shafey1; Wael Sabry Mohamed   2; Rokaya Aly Sobh 3
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| 1National Research Center | ||||
| 2National research centre | ||||
| 3National Research Centre, polymers and pigments department | ||||
| Abstract | ||||
| Polyethylene terephthalate /Montmorillonite clay nanocomposite was prepared using commercially modification Montmorillonite (MMT). The prepared nanocomposite was characterized using scanning electron microscope (SEM). Fibers of pure Polyethylene terephthalate (PET) and Polyethylene terephthalate /montmorillonite clay nanocomposite (PET/MMT) were produced using melt spinning technique. Grafting of Acrylic acid was performed using grafting emulsion polymerization technique to obtain PET/MMT-g-AA fibre and the prepared fibers were characterized using mechanical properties, FTIR in addition to SEM analysis. The results show that the PET/MMT-g-AA fibre have higher mechanical properties, and lower water absorption than pure PET and PET/MMT fibers in addition to high degree in homogeneity between PET and MMT clay in PET/MMT fibre. Clindamycin drug was successfully loaded into PET, PET/MMT and PET/MMT-g-AA fiber via solvent immersion method with different drug fiber ratio in presence of glyoxal crosses linker. Drug release profile was studied for 120 min and the results showed that about 41% from the initial loaded drug was released from the fiber after an hour of release starting time. | ||||
| Keywords | ||||
| Polypropylene / tallow /Montmorillonite / Melt Spinning / clindamycin / transdermal / drug delivery | ||||
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