Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients
El-Korany, W., Zahran, W., Alm El-Din, M., Al-Shenawy, H., Soliman, A. (2024). Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients. EKB Journal Management System, 62(1), 76-84. doi: 10.21608/ejaps.2024.257606.1083
Wael A. El-Korany; Walid E. Zahran; Mohamed A. Alm El-Din; Hanan A. Al-Shenawy; Ahmed F Soliman. "Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients". EKB Journal Management System, 62, 1, 2024, 76-84. doi: 10.21608/ejaps.2024.257606.1083
El-Korany, W., Zahran, W., Alm El-Din, M., Al-Shenawy, H., Soliman, A. (2024). 'Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients', EKB Journal Management System, 62(1), pp. 76-84. doi: 10.21608/ejaps.2024.257606.1083
El-Korany, W., Zahran, W., Alm El-Din, M., Al-Shenawy, H., Soliman, A. Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients. EKB Journal Management System, 2024; 62(1): 76-84. doi: 10.21608/ejaps.2024.257606.1083

Clinical utility of hsa-miR-181a-5p expression level in Egyptian colorectal cancer patients

Egyptian Journal of Pure and Applied Science
Volume 62, Issue 1, January 2024, Page 76-84  XML PDF (1.39 MB)
Document Type: Original Article
DOI: 10.21608/ejaps.2024.257606.1083
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Authors
Wael A. El-Korany1; Walid E. Zahranorcid 1; Mohamed A. Alm El-Din2; Hanan A. Al-Shenawy3; Ahmed F Soliman email 1
1Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
2Clinical Oncology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt
3Pathology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt
Abstract
Background: Colorectal cancer (CRC) is considered one of the most aggressive malignancies worldwide, with high mortality and morbidity rates because of its asymptomatic nature at the early stages. Further, CRC is affected by ethnicity and environmental factors. MicroRNAs (miRNAs) dysregulation has a high impact on CRC development and progression, thus this study was conducted to explore hsa-miR-181a-5p expression level in the sera of Egyptian CRC patients and assess its clinical utility.
Methods: Relative hsa-miR-181a-5p expression level was determined using quantitative real-time PCR in 192 specimens collected from 160 CRC patients and 32 healthy subjects.
Results: Hsa-miR-181a-5p relative expression was significantly up-regulated in CRC patients compared to controls and was found to be associated with increased susceptibility to CRC. Moreover, the expression level of hsa-miR-181a-5p had a powerful diagnostic performance to detect CRC, although it is still inferior to that of carcinoembryonic antigen (CEA) and cancer antigen 19.9 (CA 19.9).
Conclusion: Over-expressed hsa-miR-181a-5p may contribute to the pathogenesis of CRC, and it seems to be a valuable diagnostic biomarker to discriminate between CRC patients and healthy subjects.
Keywords
Biomarker; Cancer antigen 19.9 (CA 19.9); Carcinoembryonic antigen (CEA); Colorectal cancer (CRC); Hsa-miR-181a-5p
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