ASSESSING THE IN VITRO ANTIOXIDANT AND CYTOTOXIC PROPERTIES OF ALPINIA OFFICINARUM AND HUMULUS LUPULUS EXTRACTS | ||||
| Minia Journal of Agricultural Research and Development | ||||
| Volume 44, Issue 1, March 2024, Page 15-30 PDF (661.43 K) | ||||
| DOI: 10.21608/mjard.2024.340105 | ||||
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| Abstract | ||||
| BSTRACT In this study, we investigated the cytotoxic and antioxidant properties of acetone extracts obtained from Alpinia officinarum (Al. officinarum) and Humulus lupulus (H. lupulus). The assessment encompassed the computation of the extracts' total flavonoid content (TFC) and total phenolic content (TPC), revealing noteworthy concentrations of both phenolic and flavonoid components. According to DPPH and FRAP tests, both extracts had high antioxidant activity. Their low IC50 values suggested that they were capable of scavenging free radicals. Several bioactive substances were detected in each extract by gas chromatography-mass spectrometry (GCMS) analysis. These chemicals included ç-Sitosterol and n-Hexadecanoic acid in Al. officinarum and vitamin E and α-amyrin in H. lupulus. These results point to the plant extracts' potential for therapeutic use. Furthermore, assessments of the cytotoxicity of hepatocellular carcinoma (HepG2), lung cancer (A549), and breast cancer cell lines (MCF-7). The Al. officinarum extract shown strong cytotoxicity against each of the three cell lines, with IC50 values for each cell line ranging from 107.10 μg/mL to 51.57 μg/mL and greater than 100 μg/mL. H. lupulus extract exhibited cytotoxic properties as well, with IC50 values greater than 100 μg/mL. These results highlight the potential of extracts from Al. officinarum and H. lupulus as sources of bioactive components with cytotoxic and antioxidant qualities, indicating their potential use in the creation of innovative medications. The significance of medicinal plants in the search for novel therapeutic molecules is highlighted by this study. | ||||
| Keywords | ||||
| Al. officinarum; H. lupulus; GC-MS; HepG2; A549; MCF-7 | ||||
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