Pinuspalustrols A & B, Two Rare Dimeric Abietane-O-O-Abietane-Type Diterpenoids of Natural Colophony from Pinus palustris | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 06 February 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.260239.9134 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed H AbdEl-Razek   1; Ahmed Soliman2; Mohamed abo Elmagd3; Ahmed Hamed Eldesoky 4
| ||||
| 1Institute of Pharmaceutical Industries Research, Chemistry of Natural Compounds Department, National Research Center, , 33 El-Buhouth St., Dokki, Giza 12622, Cairo, Egypt. | ||||
| 2Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Center (NRC), El-Behoos St. 33, 12622Dokki-Giza, Egypt | ||||
| 3Department of Pharmacognosy, Institute of Pharmaceutical and Drug Industries Research, National Research Centre (NRC), 33 El-Behouth St., Dokki, Giza, P.O. 12622, Egypt | ||||
| 4Department of Pharmacognosy, Institute of Pharmaceutical and Drug Industries Research, National Research Centre (NRC), 33 El-Behouth St., Dokki, Giza, P.O. 12622, Egyptational Research Centre Pharmacognosy Natural Product Chemistry | ||||
| Abstract | ||||
| Pinus palustris' natural colophony produced two novel secondary metabolites, pinuspalustrols A (1) & B (2), a unique pair of C-7 epimeric dimers based on abietane-type diterpenoids linked via C7-C12' peroxy conjunction system. Additionally, their biogenesis-related diterpenoid monomers were previously reported (3-10). Spectroscopic techniques, particularly 1D and 2D NMR together with HREIMS, were used to elucidate their planar structures, while their relative configurations were decided by NOESY spectra, together with comparison with NMR data of known analouges. Both pinuspalustrols A (1) and B (2) possess a skeleton of 12-Hydroxyabieta-8,11,13-trien-7-yl 6-Hydroxy-7-oxoabieta-8,11,13-trien-12-yl peroxide, but they are epimeric at position 7. It is noteworthy that chemical compounds 3-10 were first isolated from P. palustris. | ||||
| Keywords | ||||
| Colophony; Pinus palustris; Pinaceae; dimeric abietane; diterpenoid | ||||
|
Statistics Article View: 60 |
||||
