An Overview about Possible Roles of Dapsone and Adapalene in Treatment of Acne Vulgaris: A Review Article | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 11 February 2024 | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/zumj.2024.265767.3142 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amr Nazir Saadawi1; Amany Abdelrahman Nassar1; Fakher Eldin Soliman Ghazy2; Mohamed Ibrahim El ghareeb1; Norhan Atef Abdraboh Aboelkhair  1
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| 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Zagazig university | ||||
| 2Pharmaceutics and Industrial Pharmacy Department, Faculty of Medicine, Zagazig university | ||||
| Abstract | ||||
| Background: Inflammatory lesions such as papules, pustules, or nodules, as well as open or closed comedones, defined as acne, which is a chronic inflammatory disease. A lot of young people get this skin condition, which is why it's so frequent. Several factors may influence the choice of therapy including age of the patient, extent, severity of the disease and sites involved. Topical treatment can be used alone or with combination to other topical or oral agents. We intended to provide an outline of possible roles of Dapsone and Adapalene in Treatment of Acne Vulgaris. Conclusion: Nodulocystic acne and other severe forms of acne frequently necessitate systemic medication. Although systemic isotretinoin is widely considered the best treatment for stubborn acne, it comes with a range of well-known adverse effects. Applying a thin layer of 5% dapsone gel to afflicted lesions is indicated for the treatment of acne vulgaris, and the product has FDA approval. Adapalene (ADP) and other retinoids are used to treat acne vulgaris with the goal of removing these causes and reducing or eliminating acne lesions. In comparison to benzoyl peroxide, a 0.1% ADP is more effective at keratolysis. These effects of ADP have been found to be effective in treating hyperkeratosis. Also, ADP's corneum layer has poor percutaneous absorption, so it stays active in the skin and hair follicles for longer—an important area for treating acne vulgaris | ||||
| Keywords | ||||
| Dapsone; Adapalene; Acne Vulgaris | ||||
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