The Association between ATP-Binding Cassette C2 (ABCC2) Transporter Genetic Polymorphism and Peripheral Neuropathy in Gastrointestinal Cancer Patients Receiving Oxaliplatin. | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Volume 8, Issue 1, June 2024, Page 1-12 PDF (551.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aps.2023.254995.1153 | ||||
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| Authors | ||||
Sara Mohamed Abdel Aziz  1; Diaa Eldin Moussa Sherif2; Nagwa Sabri 3; May Ahmed Shawki3
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| 1Clinical Pharmacy Department, Faculty of pharmacy, Ahram Canadian University, Giza, Egypt | ||||
| 2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||||
| Abstract | ||||
| Introduction: Single nucleotide polymorphisms (SNPs) in ATP-binding cassette C2 (ABCC2) gene may lead to higher intracellular oxaliplatin accumulation in the dorsal root ganglia and thus increased risk of oxaliplatin-induced peripheral neuropathy (OXAIPN). Aim: to study the association between the SNPs rs1885301 G>A, rs4148396 C>T and rs3740066 C>T in ABCC2 gene and the incidence of OXAIPN in gastrointestinal cancer patients. Patients and Methods: The study was prospective cohort study carried out at the Clinical Oncology Department, Ain Shams University Hospitals. Eligible patients received FOLFOX6 and FOLFIRINOX for 8-12 cycles. The SNPs assessment was performed using Real-time PCR using Rotor gene Q (QIAGEN®) system. The patients were followed up with each cycle to assess the incidence and severity of OXAIPN and other common toxicities including diarrhea, vomiting and neutropenia. Results: One hundred and twenty patients were included in the study. The minor allele frequency for the SNPs rs1885301 G>A, rs4148396 C>T and rs3740066 C>T were 0.4 ,0.2 and 0.3 respectively. The current study showed no association between the three SNPs and the incidence and grade of OXAIPN with less than 50% of the participants reported grade III and IV peripheral neuropathy. A significant association was found between rs4148396 C>T and the occurrence of neutropenia where TT haplotype showed significant higher incidence of neutropenia compared to CC + CT. Conclusion: Further large sample size study is recommended to confirm the association between rs4148396 C>T and the incidence of neutropenia in Egyptian gastrointestinal cancer patients in different populations. | ||||
| Keywords | ||||
| ABCC2 Transporter; Genetic Polymorphism; Peripheral neuropathy; Gastrointestinal Cancer; Oxaliplatin | ||||
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