Selective and efficient Cu-catalyzed 1,3-bipolar cycloaddition of propargylthiobenzoxazoline and aryl azides | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 9, September 2024, Page 523-529 PDF (638.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.167226.7060 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Burkhon Zhurayevich Elmuradov   1; Zulkhumorkhon Jalolidin qizi Pulatova 2; Ilkhom Sobirovich Ortikov 2
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| 1Department of organic synthesis, S. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Mirzo-Ulugbek | ||||
| 2Department of organic synthesis, S. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Mirzo-Ulugbek str., 77, Tashkent, Uzbekistan | ||||
| Abstract | ||||
| It was selectively carried out synthesis of S-propargylthiobenzoxazoline (2). An effective synthesis method of 2-propargylthiobenzoxazoline was found and a cheap and convenient method of synthesis of new benzoxazole-triazole hybrid molecules (3-9) was developed by carrying out 1,3-bipolar cycloaddition reactions of the obtained 2-propargyl-derivative with some aromatic azides. Factors influencing the course and direction of the reaction (catalyst nature, ratio of reagents, reaction temperature and duration) have been identified. The IR-, 1H and 13C NMR spectra of the obtained substances were analyzed and it was proved that they correspond to their structures. | ||||
| Keywords | ||||
| 2-propargylthiobenzoxazoline; arylazides; 1; 3-bipolar cycloaddition; Cu (I) halides; hybrid molecules | ||||
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