The Possible Ameliorative Effect of Vitamin C Against Amoxicillin-Clavulanic Acid Toxicity in the liver of Adult Male Albino Rats | ||||
| Sohag Medical Journal | ||||
| Volume 28, Issue 2., 2024, Page 64-73 PDF (1.16 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2024.256388.1437 | ||||
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| Authors | ||||
Hanaa Abdel Sattar Mohammed1; Ahmed Talaat galal2; Mohammed Abdel Rahman Mahmoud1; yasmeen bander hosny  1
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| 1Anatomy faculty of medicine Sohag university | ||||
| 2Anatomy department,assuit university,assuit,assuit | ||||
| Abstract | ||||
| Background: Amoxicillin/clavulanic acid (AC) is used to treat a variety of bacterial infections, most frequently linked to drug-induced hepatotoxicity. Vitamin C is a necessary, water-soluble micronutrient serves as an antioxidant and cofactor for several enzymes, Aim of the work: Our research aimed to study the potential Ameliorative role of vitamin C against the amoxicillin- clavulanic acid induced hepatotoxic effects on the liver of the adult male albino rats. Materials and methods: 30 adult albino rats were used. The animals were equally divided into three groups, each of them consisting of 10 rats. Group I: "control" Animals were not subjected to any interference. Group II: were given Amoxicillin-Clavulanic Acid induced Hepatotoxicity. Group III: were given Amoxicillin-Clavulanic Acid induced Hepatotoxicity and Vitamin C treated it. At the end of the experiment, blood samples and livers were collected for biochemical and histological evaluation. Results: Administration (AC) had apparent hepatotoxic effects in the form of elevations in blood liver enzymes, disruption of the antioxidant capacity of liver tissue. Co-administration of Vitamin C could reduce all the biochemical and histological effects of AC. Conclusion: Vitamin C a has protective and therapeutic effects on AC-induced liver damage in rats. Keywords: liver, Amoxicillin/clavulanic acid, Vitamin C, Rats | ||||
| Keywords | ||||
| Keywords: liver; Amoxicillin/clavulanic acid; Vitamin C; Rats | ||||
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