The Diagnostic Value of Tzanck Test in Vesiculobullous, Pustular, and Oral Lesions in The Dermatology Clinic | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 16, Volume 75, Issue 6, April 2019, Page 3052-3059 PDF (607.89 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2019.34217 | ||||
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Authors | ||||
Amira Ahmed Adel Abdel Azim1; Gamal El-Din Abd El-Hamid El-Sayed2; Marwa Said Mahmoud1; Heba Ibrahim Mostafa Ibrahim1 | ||||
1Department of Dermatology and Venereology, Faculty of Medicine - Al-Azhar University | ||||
2Department of Pathology, Faculty of Medicine - Al-Azhar University | ||||
Abstract | ||||
Background: Vesiculobullous disorders represent a heterogeneous group of dermatoses with protean manifestations. The accurate diagnosis of bullous disorders of the skin and mucous membrane requires evaluation of clinical, histological, and immunofluorescence findings. Objective: The aim of this study was to investigate Tzanck smear findings and to determine the diagnostic value of this test in moist (erosive, vesicular, bullous, and pustular) skin and oral lesions. Patients and Methods: This cross sectional study was conducted on one hundred patients presented with vesicular, bullous, and pustular skin lesions and/or oral lesions. All patients were included from Dermatology Outpatient Clinic at Al-Zahraa University Hospital over the period from March 2018 to March 2019. Results: Positivity of multinucleated giant cells in herpetic infection, acantholytic cells in pemphigus, dyskeratotic acantholytic cells and cocci in bullous impetigo were useful landmarks in Tzanck smear. A decrease in viral shedding from herpetic lesions of longer duration may correlate with the lower sensitivity of the Tzanck smear. Therefore, in this study we excluded the lesions older than 3 days. The percentage of positivity in vesicles was much higher than that of pustules. Conclusion: According to this study, Tzanck smear was an inexpensive, simple, and rapid test and did not require any specialized laboratory equipment for evaluation of various vesiculobullous and pustular lesions either skin or mucosal one. | ||||
Keywords | ||||
Tzanck test; Vesiculobullous; Pustular; oral lesions; Dermatology | ||||
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