Pyrimidine-5-carbonitriles: A review of available synthetic approaches and biological evaluation for promising compounds over the last decade

Edris, Nada A.; Kadry, Hanan H.; Taher, Azza T.; Adly, Mina E.

doi:10.21608/ejchem.2024.264757.9231

	Pyrimidine-5-carbonitriles: A review of available synthetic approaches and biological evaluation for promising compounds over the last decade
Egyptian Journal of Chemistry
Volume 67, Issue 9, September 2024, Page 439-462 PDF (4.28 MB)
Document Type: Review Articles
DOI: 10.21608/ejchem.2024.264757.9231
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Authors
Nada A. Edris¹; Hanan H. Kadry²; Azza T. Taher²^{, 3}; Mina E. Adly ²
¹Internal Pharmacist at Banha University Hospitals, Al-Qalyubia, Cairo
²Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, Cairo University, Cairo 11562, Egypt.
³Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, October 6 University (O6U), 6th of October City 12585, Egypt, Giza, Egypt
Abstract
The structural diversity and biological significance of pyrimidine core attracted the attention of many researchers and scientists in the past years owing to their inclusion in the composition of most nucleotides, including DNA and RNA. One unique scaffold was pyrimidine-5-carbonitrile and its importance is largely related to a wide range of biological activities of pyrimidine-5-carbonitrile derivatives such as anticancer, antimicrobial, anti-inflammatory, antifungal, antitubercular, antiviral, antihypertensive, anthelmintic, anticonvulsant, and antimalarial. The key point of this review is to collect and review the most recent and available synthetic pathways for pyrimidine-5-carbonitrile derivatives from different starting materials and focus on the promising derivatives with valuable pharmacological activities.
Keywords
Pyrimidine-5-carbonitrile; Biological activity


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