The Effect of Vitamin D Deficiency on the Frozen-Thawed Embryo Transfer Outcome | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 106, Volume 94, Issue 1, January 2024, Page 725-732 PDF (565.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2024.342687 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| Background: Vitamin D (vit D) regulates the female reproductive system and inflammation reduction. Vit D deficiency has been reported to be related to various diseases, such as infertility in females. Objective: This work aimed to study the effect of vitamin D deficiency and vaginal inflammation on the pregnancy rate following frozen embryo transfer. Subjects and Methods: This prospective study included 188 infertile females who underwent ICSI protocol between February 2021 and January 2022. The individuals were categorized into two groups: Group I (Vit D deficiency, vit D < 30 ng/mL), and group II (Normal vit D ≥ 30 ng/mL). Vitamin D levels in serum and vaginal inflammation were detected, and pregnancy outcomes were compared between the groups. The impact of vitamin D deficiency and vaginal inflammation on the pregnancy rates was investigated. Results: Among participants, 74.3% had vitamin D deficiency, and 25.5% had normal vit D levels. 37.23% of patients had a positive β-hCG, while 62.77% had negative β-hCG. 14.9% of cases had no vaginal infection, while 85.1% had a vaginal infection. There was a statistically significant correlation between lower pregnancy rates in Egyptian females and vit D deficiency (p < 0.001). However, there was no correlation association between vaginal inflammation and pregnancy rates (p > 0.05). Logistic regression analysis showed that reduced pregnancy outcome could be due to vit D (P<0.001). Conclusion: Lower pregnancy rates following ICSI among Egyptian women may be related to vitamin D deficiency, while vaginal inflammation has no impact on pregnancy rates. | ||||
| Keywords | ||||
| Frozen embryo transfer (FET); Intracytoplasmic sperm injection (ICSI); Infertility; Pregnancy rates; Vitamin D | ||||
|
Statistics Article View: 56 PDF Download: 65 |
||||
