Study of Vitamin D Status and Non Alcoholic Fatty Liver Disease in Obese and Normal Weight Subjects with Different Metabolic Phenotypes: A Case Control Study | ||||
| The Medical Journal of Cairo University | ||||
| Volume 91, Issue 12, December 2023, Page 1607-1616 PDF (627.13 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2024.342765 | ||||
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| Author | ||||
| OLA A. SALAMA, M.D.*; MANAL M. ABDELMAGEED, M.D.** ZZA S. ABDOU, M.D.* . | ||||
| The Department of Human Physiology*, Experimental & Clinical Internal Medicine Department**, Medical Research Institute, Alexandria University | ||||
| Abstract | ||||
| Abstract Background: Obesity is a common metabolic disorder and is usually associated with non-alcoholic fatty liver disease (NAFLD). Aim of Study: This study aimed to determine vitamin D lev-el and presence of NAFLD in obese and normal weight subjects with different metabolic phenotypes. Patients and Methods: Twenty-five obese and twenty-five non obese healthy adult males were included Anthropometric measurements, serum vitamin D level, diagnosis of NAFLD by ultrasonography and fatty liver index (FLI) were performed. Metabolic health profile was determined in all subjects with classification of each group into metabolic healthy and un-healthy subgroups. ANOVA was used for comparing the four studied groups and followed by Post Hoc test (Tukey) for pair-wise comparison. And Person coefficient was used to correlate between normally distributed quantitative variables. Results: Significant lower serum vitamin D level and disturbed metabolic profile were observed in metabolically unhealthy obese (MUO) subgroup than the other studied sub-groups (p<0.001). Both metabolically unhealthy normal weight (MUNW) and MUO subgroups showed lower levels as com-pared to their corresponding healthy ones (p<0.001). 90% of metabolically healthy obese (MHO) and 933% MUO had fatty liver. While only 7.7% of metabolically healthy normal weight (MHNW) and 333% of MUNW had fatty liver. Significantly negative correlations were noticed between serum vitamin D levels and body mass index (BMI), serum triglycerides (TG), low density lipoprotein (LDL), homeostasis model assessment for insulin resistance (HOMA-IR), high sensitive C reactive protein (hs-CRP), and fatty liver index (FLI) in MHO, MUNW and MUO subgroups. Conclusion: Disturbed metabolic health could be related to low vitamin D and NAFLD in obese and normal weight subjects. | ||||
| Keywords | ||||
| Vitamin D — Non alcoholic fatty liver disease —Obesity — Metabolic phenotypes | ||||
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