Age-related Neovascularization Response to Intravitreal Anti-vascular Endothelial Growth Factor | ||||
| Suez Canal University Medical Journal | ||||
| Article 8, Volume 27, Issue 1, January 2024, Page 73-82 PDF (248.63 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2024.342793 | ||||
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| Authors | ||||
Mohamed S. Omar  ; Osama M. ELBassiouny; Hussein S. EL-Nahass; Tarak M. Radwan; Mervet E. Elgharib
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| Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt | ||||
| Abstract | ||||
| Background: A medical disorder called age-related macular degeneration (AMD) can cause impaired or absent vision in the center of the visual field. Initially, there are frequently no symptoms. A non-invasive imaging method called Spectral Domain Optical Coherence Tomography (SD-OCT) can show structural alterations in the retinal pigment epithelium (RPE) and neurosensory retina. Anti-vascular endothelial growth factor Anti-VEGF is often administered intravitreally to slow or stop the formation of blood vessels by blocking its interaction with receptors on the surface of endothelial cells. Aim: To describe changes in age-related choroidal neovascularization CNV to intravitreal anti-VEGF using OCTA. Methods: We conducted a prospective quasi-experimental study on 30 eyes of patients with neovascular AMD at the Suez Canal University Hospital's Ophthalmic Outpatient Clinic to observe how CNV responded to anti-VEGF for improved visual results and more effective follow-up in this patient group. Results: There was a highly statistically significant difference between different periods regarding both CNV area (p < 0.001), and CNV fine vessel density (p < 0.001). Conclusion: OCT-A is a quick, non-invasive, and repeatable way to examine exudative AMD. It offers precise data on the region of the CNV that responds to anti-VEGF treatment, and it is a promising imaging technique that permits assessment of the CNV fine vascular density response to anti-VEGF. | ||||
| Keywords | ||||
| Macular Degeneration; Optical Coherence Tomography | ||||
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