A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients
Abdelsamea, S., Khashaba, R., Amer, A., Abd Allah Ahmed khalifa, O., Ameen, S. (2024). A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients. EKB Journal Management System, 41(1), 94-100. doi: 10.21608/bmfj.2024.265553.2004
Soheir Abdelrahman Abdelsamea; Rana Atef Khashaba; Arwa S. Amer; Omnia Abd elmonsef Abd Allah Ahmed khalifa; Seham Gouda Ameen. "A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients". EKB Journal Management System, 41, 1, 2024, 94-100. doi: 10.21608/bmfj.2024.265553.2004
Abdelsamea, S., Khashaba, R., Amer, A., Abd Allah Ahmed khalifa, O., Ameen, S. (2024). 'A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients', EKB Journal Management System, 41(1), pp. 94-100. doi: 10.21608/bmfj.2024.265553.2004
Abdelsamea, S., Khashaba, R., Amer, A., Abd Allah Ahmed khalifa, O., Ameen, S. A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients. EKB Journal Management System, 2024; 41(1): 94-100. doi: 10.21608/bmfj.2024.265553.2004

A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients

Benha Medical Journal
Article 10, Volume 41, Issue 1, March and April 2024, Page 94-100  XML PDF (501.76 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.265553.2004
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Authors
Soheir Abdelrahman Abdelsamea1; Rana Atef Khashaba2; Arwa S. Amerorcid 3; Omnia Abd elmonsef Abd Allah Ahmed khalifa email 4; Seham Gouda Ameen5
1Department of Clinical and Chemical Pathology, Faculty of medicine, Benha University
2Department of Clinical and Chemical Pathology, Faculty of medicine, Banha University.
3Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of medicine, Benha University
4M.B.B.CH Clinical and Chemical Pathology, Faculty of medicine, Benha University
5Department of clinical pathology-Faculty of medicine-Benha University
Abstract
Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by joint destruction, chronic inflammation, and autoantibody production. IL-21 plays an essential role in the immunopathology of RA. The aim of the study: was to investigate the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients and to find out its relation to disease activity. Methods: This case control study was conducted on 100 subjects; divided into two groups:Group(I):70 RA patients,Group(II):30 apparently healthy matched subjects.Through history taking, clinical examination and assessment of IL-21 gene rs2055979 by quantitative Real Time PCR (qRT-PCR).Disease activity was evaluated using DAS-28 score. Results: RA patients were significantly associated with higher frequency of rs2055979 AA genotype and A allele (p= 0.023, 0.028 respectively) with risk to develop RA.IL-21 genotypes AA and CA were significantly associated with higher DAS-28 when compared to CC genotype (p≤0.05). Conclusion: Our results showed that genetic alterations in the IL-21 gene are associated with susceptibility to rheumatoid arthritis in the Egyptian population.
Keywords
Rheumatoid arthritis; IL-21 gene; autoimmune disease; polymorphisms
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