Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs
Abdel Rahman, A., Sobhy, A., Hawata, M., Zayed, E., Awad, H., El-Sayed, W. (2024). Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs. EKB Journal Management System, 67(13), 393-402. doi: 10.21608/ejchem.2024.257696.9043
Adel A.-H. Abdel Rahman; Asmaa Sobhy; Mohamed A. Hawata; Ehab M. Zayed; Hanem M. Awad; Wael A. El-Sayed. "Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs". EKB Journal Management System, 67, 13, 2024, 393-402. doi: 10.21608/ejchem.2024.257696.9043
Abdel Rahman, A., Sobhy, A., Hawata, M., Zayed, E., Awad, H., El-Sayed, W. (2024). 'Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs', EKB Journal Management System, 67(13), pp. 393-402. doi: 10.21608/ejchem.2024.257696.9043
Abdel Rahman, A., Sobhy, A., Hawata, M., Zayed, E., Awad, H., El-Sayed, W. Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs. EKB Journal Management System, 2024; 67(13): 393-402. doi: 10.21608/ejchem.2024.257696.9043

Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs

Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Page 393-402  XML PDF (406.19 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.257696.9043
View on SCiNiTO View on SCiNiTO
Authors
Adel A.-H. Abdel Rahman1; Asmaa Sobhy1; Mohamed A. Hawata1; Ehab M. Zayed email orcid 2; Hanem M. Awad3; Wael A. El-Sayed4
1Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt
2Green Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt
3Tannic and Leather Materials Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt
4Photochemistry Department, National Research Centre, Dokki, Giza, Egypt
Abstract
1,2,4-Triazolopyrimidinen and their isosteric analogs such as triazolopyridine have possessed their interest in, the literature, due to the reported broad spectrum of bioactivities, one of which is the anticancer activity. In the current study, new functionalized 1,2,4-triazoles based substituted quinazoline system were prepared via multistep reactions starting from simple starting compounds. The reactions lead to the formation of the bi- and tricyclic 1,2,4-triazolopyridine and 1,2,4-triazolopyrimidine compounds from the S-alkylhydrazide, the ester and the hydrazine derivatives of the quinazoline system, respectively. The structures were characterized and confirmed by NMR, mass, and IR spectra. The anticancer activity revealed that several of the triazolopyrimidines based quinazoline structures especially those with theN-alkyl substitution in the quinazoline system were the most potent derivatives with results comparable to doxorubicin reference drug, the reference potent compound in the current investigation.
Keywords
quinazoline; triazolopyrimidine; triazolopyridine; hydrazide; anticancer
Statistics
Article View: 138
PDF Download: 141