Quinazolines Linked to Sugar Derivatives as Nucleoside Analogs, Synthesis and Biological Aspects

Abdel-Rahman, Adel A.-H.; El-Ganzoury, Eman M.; Zeid, Ibrahim F.; Zayed, Ehab M.; El-Sayed, Wael A.

doi:10.21608/ejchem.2024.259301.9116

	Quinazolines Linked to Sugar Derivatives as Nucleoside Analogs, Synthesis and Biological Aspects
Egyptian Journal of Chemistry
Volume 67, Issue 9, September 2024, Page 209-223 PDF (2.19 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.259301.9116
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Authors
Adel A.-H. Abdel-Rahman ¹; Eman M. El-Ganzoury ¹; Ibrahim F. Zeid¹; Ehab M. Zayed ²; Wael A. El-Sayed ³
¹Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt
²Green Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt
³Photochemistry Department, National Research Centre, Dokki, Giza, Egypt
Abstract
Quinazoline incorporating compounds have recently acquired intensive interest due to their several applications, the most important of which are those related to the divers bioactivities. Quinazoline derivatives have a variety of pharmacological effects providing a special interest to such heterocyclic systems as a basic core in bioactive structures. Techniques for synthesizing or modifying this ring structure are therefore always evolving and intriguing. As intermediates in the synthesis of various beneficial heterocyclic compounds, they are of considerable interest. Incorporation of sugar, in modified cyclic and acyclic forms, with the structure of heterocyclic possessing quinazoline system revealed potential structures with various bioactivities.
Keywords
Quinazolinyl; synthesis; anticancer; antimicrobial; antiviral


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