Diagnostic Value of Interleukin-33 in Neonatal Sepsis
Salem, A., Farag, D., Ahmed, M., Botrous, O. (2024). Diagnostic Value of Interleukin-33 in Neonatal Sepsis. EKB Journal Management System, 5(1), 133-142. doi: 10.21608/ejmr.2023.210449.1388
Aida Mohamed said Salem; Dalia Sharawy Farag; Mai Esam Ahmed; Osama Ezzat Botrous. "Diagnostic Value of Interleukin-33 in Neonatal Sepsis". EKB Journal Management System, 5, 1, 2024, 133-142. doi: 10.21608/ejmr.2023.210449.1388
Salem, A., Farag, D., Ahmed, M., Botrous, O. (2024). 'Diagnostic Value of Interleukin-33 in Neonatal Sepsis', EKB Journal Management System, 5(1), pp. 133-142. doi: 10.21608/ejmr.2023.210449.1388
Salem, A., Farag, D., Ahmed, M., Botrous, O. Diagnostic Value of Interleukin-33 in Neonatal Sepsis. EKB Journal Management System, 2024; 5(1): 133-142. doi: 10.21608/ejmr.2023.210449.1388

Diagnostic Value of Interleukin-33 in Neonatal Sepsis

Egyptian Journal of Medical Research
Volume 5, Issue 1, January 2024, Page 133-142  XML PDF (390.45 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2023.210449.1388
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Authors
Aida Mohamed said Salem1; Dalia Sharawy Farag email 1; Mai Esam Ahmed2; Osama Ezzat Botrous1
1Pediatrics department, Faculty of Medicine, Beni-Suef University
2Clinical and chemical Pathology department, Faculty of Medicine, Beni-Suef University
Abstract
Background: Most infant deaths are attributed to neonatal sepsis. Reduced morbidity and mortality can be achieved with prompt diagnosis. Due to the disease's rapid course, accurate utilization of disease-specific biomarkers is crucial for timely diagnosis and treatment. Aim and objective: This study aimed to find out serum IL33 levels in neonates with sepsis and to investigate its role in the identifying of neonatal sepsis. Methods: Case-control research was performed on 45 cases diagnosed with neonatal sepsis with positive blood cultures and 45 healthy neonates as controls. A peripheral blood sample was taken from the patients and controls then IL33 levels were measured by ELISA. Results: In newborn sepsis individuals, serum IL 33 levels were significantly greater than in healthy controls (203.9±63.1vs.127.4±30.5 ng/ml, respectively: p less than 0.001). Serum IL33 levels were significantly positively correlated with CRP levels in neonatal sepsis patients. IL33 is increased in survivor than in non-survivor cases. Conclusion: Elevated levels of interleukin 33 strongly correlate with neonatal sepsis so it might function as a reliable a diagnostic indicator for neonatal sepsis.
Keywords
Neonate; IL33; Sepsis; Marker
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