Study of mineral and bone disorders in Minia University Hospital dialysis patients | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 26 February 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2024.267604.1658 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amany Salah Ahmed  1; Sharehan abdelrahman Ibrahim2; Amal Kamal Helmy3; Osama Nady Mohamed2; Doaa Elzaeem Ismail4; Asmaa Kassem Kasem5
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| 1Intenal medicine, Faculty of medicine, Minia universty, Minia, Egypt | ||||
| 2Internal medicine, Faculty of medicine,Minia unevirsty, Minia, Egypt | ||||
| 3Nephrology unit, Department of Internal Medicine, Faculty of Medicine -Minia University | ||||
| 4Department of Clinical Pathology, Faculty of Medicine, Minia University, El-Minia, Egypt | ||||
| 5Endocrinology and Diabetes unit, Internal medicine department, Faculty of medicine, Minia university. | ||||
| Abstract | ||||
| Background: Chronic renal disease-MBD is characterized by irregularities in the metabolism of calcium, phosphorus, PTH, or vitamin D, and abnormalities in mineralization, bone turnover, and the calcification of soft tissues or blood vessels (1). Serum parathormone or bone-specific alkaline phosphatase measurements can be utilized to evaluate bone disease, as elevated or diminished values indicate underlying bone turnover (2). Methods: The study included ninety patients with end stage renal disease (ESRD) undergoing regular hemodialysis at the hemodialysis unit at El-Minia University Hospital. After obtaining informed consent, laboratory tests conducted, including a complete blood count, blood sugar, lipid profile, CRP, blood urea, serum creatinine, albumin, total calcium, phosphate, bone specific alkaline phosphatase, and PTH level evaluation. Results: Hyper-parathyroid bone disease was prevalent in 23.3% of the studied patients and low parathyroid level in 10% of the studied patients and Serum calcium and bone-specific alkaline phosphate levels show high significant correlation with PTH level. Symptoms of MBD were common in both low and high bone turnover populations. According to the study, 57% of the individuals had hypocalcemia. In 66.7% of the patients, PTH was within the regulated range. Conclusion: Depending on abnormal PTH levels (23.3% of patients with high PTH levels and 10% with low PTH levels), the percentage of MBD among the HD patients under study was 33.3%. The majority of patients with low PTH levels had high serum Ca and low bone specific alkaline phosphatase. Patients with high PTH levels had low serum Ca and high bone specific alkaline phosphatase. | ||||
| Keywords | ||||
| chronic kidney disease‑mineral bone disorder; Bone specific alkaline phosphatase; mineral bone disorder; Hypocalcemia | ||||
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