Association of anti-thyroid peroxidase antibody among Euthyroid women with adverse pregnancy outcomes | ||||
| Middle East Journal of Medical Genetics | ||||
| Articles in Press, Accepted Manuscript, Available Online from 27 February 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mxe.2024.254631.1010 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mai M. Shaker  1; Taghreed A. Shalabi2
| ||||
| 1Prenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Institute, National Research Centre. Cairo, Egypt. | ||||
| 2Prenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Institute, National Research Centre. Cairo, Egypt. | ||||
| Abstract | ||||
| ABSTRACT Background: Thyroid autoimmunity (TAI) can have an adverse impact on pregnancy outcomes. Thyroid peroxidase (TPO) is a main enzyme needed in thyroid hormones; important autoantigen in autoimmune thyroid diseases. Methods: It is a prospective study . 250 women in euthyroid state were screened for positive existence of anti-TPO Ab. 40 out of 250 were positive for anti TPO antibodies. Those 40 Euthyroid pregnant females were observed , and outcomes were compared to gestation matched controls pregnant women (anti-TPO negative) using Elisa. Results: Anti-TPO positivity among screened pregnant women was 16%. Anti-TPO positive, euthyroid females had a higher occurrence of pregnancy loss 22.5 % vs. 5%; p<0.05, preterm labor 25% vs. 7.5%; p<0.05. Pregnant women positive for anti-TPO Ab had higher risk for pregnancy loss (5 folds) and for preterm labor (4 folds ) in comparison to the control . Conclusion: There is correlation between the presences of anti-TPO antibodies among pregnant women with adverse pregnancy outcomes in euthyroid state pregnant women. | ||||
| Keywords | ||||
| Key words: Antibodies; Outcome; Peroxidase; Pregnancy; Thyroid | ||||
|
Statistics Article View: 34 |
||||
