Association of prolactin, interleukin-8 genes polymorphism and the incidence of some diseases with milk production traits in Holstein-Friesian Cows
Shalan, S., Manaa, E., El-Qaliouby, H. (2023). Association of prolactin, interleukin-8 genes polymorphism and the incidence of some diseases with milk production traits in Holstein-Friesian Cows. EKB Journal Management System, 45(2), 1-6. doi: 10.21608/bvmj.2023.239378.1732
Salwa safwat Shalan; Eman abdallah Manaa; Hadeel Samy El-Qaliouby. "Association of prolactin, interleukin-8 genes polymorphism and the incidence of some diseases with milk production traits in Holstein-Friesian Cows". EKB Journal Management System, 45, 2, 2023, 1-6. doi: 10.21608/bvmj.2023.239378.1732
Shalan, S., Manaa, E., El-Qaliouby, H. (2023). 'Association of prolactin, interleukin-8 genes polymorphism and the incidence of some diseases with milk production traits in Holstein-Friesian Cows', EKB Journal Management System, 45(2), pp. 1-6. doi: 10.21608/bvmj.2023.239378.1732
Shalan, S., Manaa, E., El-Qaliouby, H. Association of prolactin, interleukin-8 genes polymorphism and the incidence of some diseases with milk production traits in Holstein-Friesian Cows. EKB Journal Management System, 2023; 45(2): 1-6. doi: 10.21608/bvmj.2023.239378.1732

Association of prolactin, interleukin-8 genes polymorphism and the incidence of some diseases with milk production traits in Holstein-Friesian Cows

Benha Veterinary Medical Journal
Volume 45, Issue 2, December 2023, Page 1-6  XML PDF (566.82 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2023.239378.1732
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Authors
Salwa safwat Shalan1; Eman abdallah Manaaorcid 2; Hadeel Samy El-Qaliouby email orcid 3
1Animal wealth development department , faculty of veterinary medicine, benha university
2Animal wealth development departement, faculty of veterinary medicine, benha university
3Animal wealth development, faculty of veterinary medicine, Beha University, Toukh, egypt.
Abstract
The present study was conducted to identify the association between prolactin, interleukin-8 genes polymorphism and their effects on hormonal concentration, milk yield and composition traits in Holstein-Friesian cows. Sixty-four Holstein-Friesian milking cows from Gammasa dairy farm located close to Mansoura city were categorized into three groups based on milk yield (G1= 20 high, G2= 24 medium and G3= 20 low-producing animals). Serum, blood, and milk samples were collected from the three groups to measure hormone concentration, sequence analysis, and milk components (fat, protein, lactose, and ash). Two novel single nucleotide polymorphisms (SNPs) known as C54G and G75A were detected within the exon three of the prolactin gene. Although high-producing animals with CG prolactin genotype were more frequent in the population (0.62), and significantly showed high serum prolactin hormone concentration, the impact of these SNPs on milk yield traits was statistically non-significant. Moreover, the prolactin C54G showed a significant effect on milk components. Furthermore, there was a significant association between high-producing animals and higher incidence of mastitis. The results indicated that the population is in Hardy–Weinberg equilibrium and this suggests no change in the distribution of alleles among consequent generations. The CG SNP of the prolactin gene may be a useful marker for assisted selection programs to improve Holstein-Friesian cattle health and milk composition traits.
Keywords
Diseases and milk traits; Holstein-Friesian; Interleukin-8; Polymorphism; Prolactin
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