The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial
Ali, M., Hussein, M., Ali, R., Sobh, A., Mahmoud, A. (2024). The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial. EKB Journal Management System, 14(1), 46-54. doi: 10.21608/ebwhj.2023.245005.1268
Mohamed K. Ali; Mostafa Hussein; Reham Ali; Ahmed A. Sobh; Abdelrahman Mahmoud. "The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial". EKB Journal Management System, 14, 1, 2024, 46-54. doi: 10.21608/ebwhj.2023.245005.1268
Ali, M., Hussein, M., Ali, R., Sobh, A., Mahmoud, A. (2024). 'The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial', EKB Journal Management System, 14(1), pp. 46-54. doi: 10.21608/ebwhj.2023.245005.1268
Ali, M., Hussein, M., Ali, R., Sobh, A., Mahmoud, A. The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial. EKB Journal Management System, 2024; 14(1): 46-54. doi: 10.21608/ebwhj.2023.245005.1268

The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial

Evidence Based Women's Health Journal
Article 7, Volume 14, Issue 1, February 2024, Page 46-54  XML PDF (341.92 K)
Document Type: Original Article
DOI: 10.21608/ebwhj.2023.245005.1268
View on SCiNiTO View on SCiNiTO
Authors
Mohamed K. Ali1; Mostafa Hussein2; Reham Ali1; Ahmed A. Sobh email 1; Abdelrahman Mahmoud1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Egypt
2Obstetrics and gynecology faculty of medicine Assiut university Egypt
Abstract
Aim: To investigate the effectiveness of adding vaginal progesterone to oral omega-3 fatty acids on the birth weight of constitutionally small for gestational age fetuses (SGA).
Materials and Methods: The study was a randomized clinical trial conducted from May 2020 to June 2022 at Assiut Woman's Health Hospital, Egypt including pregnant women in singleton fetuses (26-28 weeks) whose pregnancy was associated with constitutionally SGA fetuses. The eligible women were randomized to either group I (oral omega-3 fatty acids group) or group II (vaginal progesterone plus oral omega-3 fatty acids group); given daily till delivery. The primary outcome was the mean birth weight (gm) at the time of delivery. The data were analyzed using an unpaired t-test and the Chi-square test.
Results: Eighty women were divided equally into two groups. There was a statistically significant increase in the mean birth weight (gm) at the time of delivery in group II in comparison to group I (1762.74 ± 80.06 vs. 1852.94 ± 71.71, receptively; p=0.000). The mean of uterine artery resistant index (RI) has a statistically significant decrease at 32 weeks and 36 weeks (p value=0.000) and the mean of umbilical artery RI has a statistically significant decrease at 36 weeks (p value=0.001) in group II.
Conclusion: Adding vaginal progesterone to oral omega-3 fatty acids is superior to oral omega-3 fatty acids alone in increasing the birth weight of constitutionally SGA fetuses when given from 26-28 weeks gestation till delivery. The improvement of the feto-maternal blood flow may be behind the treatment result.
Keywords
Doppler; omega-3 fatty acids; progesterone; SGA
Statistics
Article View: 68
PDF Download: 68