Evaluation of the effects of diclazuril and toltrszuril on hematological changes , antioxidant status immune response and cecal histoarchitecture of chickens experimentally infected with Eimeria tenella
Fathy, G., Farah, K., Abd El-hamied, S. (2023). Evaluation of the effects of diclazuril and toltrszuril on hematological changes , antioxidant status immune response and cecal histoarchitecture of chickens experimentally infected with Eimeria tenella. EKB Journal Management System, 45(2), 71-76. doi: 10.21608/bvmj.2023.214011.1665
Ghada Fathy; Khalid Farah; Saher S. Abd El-hamied. "Evaluation of the effects of diclazuril and toltrszuril on hematological changes , antioxidant status immune response and cecal histoarchitecture of chickens experimentally infected with Eimeria tenella". EKB Journal Management System, 45, 2, 2023, 71-76. doi: 10.21608/bvmj.2023.214011.1665
Fathy, G., Farah, K., Abd El-hamied, S. (2023). 'Evaluation of the effects of diclazuril and toltrszuril on hematological changes , antioxidant status immune response and cecal histoarchitecture of chickens experimentally infected with Eimeria tenella', EKB Journal Management System, 45(2), pp. 71-76. doi: 10.21608/bvmj.2023.214011.1665
Fathy, G., Farah, K., Abd El-hamied, S. Evaluation of the effects of diclazuril and toltrszuril on hematological changes , antioxidant status immune response and cecal histoarchitecture of chickens experimentally infected with Eimeria tenella. EKB Journal Management System, 2023; 45(2): 71-76. doi: 10.21608/bvmj.2023.214011.1665

Evaluation of the effects of diclazuril and toltrszuril on hematological changes , antioxidant status immune response and cecal histoarchitecture of chickens experimentally infected with Eimeria tenella

Benha Veterinary Medical Journal
Volume 45, Issue 2, December 2023, Page 71-76  XML PDF (561.13 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2023.214011.1665
View on SCiNiTO View on SCiNiTO
Authors
Ghada Fathy email 1; Khalid Farah2; Saher S. Abd El-hamied3
1Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Egypt
2Departement of Clinical Pathology Faculty of Veterinary Medicine, Benha University, Egypt.
3Department of Clinical Pathology, Animal Health Research Institute, Zagazig, Egypt.
Abstract
Hundred Cobb chicks of one day old were used in this study. The chicks were divided into 4 groups (n = 25 / group). Group 1 was used as a control group; groups 2, 3, and 4 were experimentally infected with Eimeria tenella (E. tenella) at the 14th day of age. G2 received no treatment; G3 and G4 were treated with diclazuril 1ml/4 L in drinking water and toltrazuril 7 mg/k.g B.wt for 2 successive days respectively at 5 days post infection. The obtained results revealed significant decreases in hemoglobin concentration, red blood cells counts and PCV% in the infected group compared with the control group. The levels of SOD were significantly decreased while MDA level was significantly increased and the levels of IL -2 and IL- 6 were increased in E. tenella infected group. Histopathological results revealed heavy infestation of the intestinal crypts with different developmental stages in Eimeria tenella infected group compared with control group. The treatment with diclazuril and toltrazuril improved the deterioration caused by E. tenella, particularly the diclazuril treated group.
Keywords
Eimeria tenella; hematological; immunological parameters; diclazuril; toltrazuril
Statistics
Article View: 46
PDF Download: 49