Correlation between Glycated Hemoglobin (HBA1c), Glycated Albumin Levels and Cardiovascular Risk Factors in Pre-Diabetic Metabolic Syndrome Patients.. | ||||
| The Medical Journal of Cairo University | ||||
| Volume 91, Issue 12, December 2023, Page 1617-1626 PDF (767.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2023.343730 | ||||
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| Author | ||||
| SHAIMAA A. FATHY, M.D.*; SAHAR S. ELWAKIL, MD.*; SHERRY E. FAYEZ, MD .*; LAILA A. RASHED, M.D.**; MENNA M. ABDEL-NABY, M.Sc.* and GHADA R. ABDEL AZIZ, M.D.* | ||||
| The Department of Internal Medicine, Endocrinology Unit* and Biochemistry Department**, Faculty of Medicine, Cairo University | ||||
| Abstract | ||||
| Abstract Background: The metabolic syndrome is a major and esca-lating public-health problem. It is a predisposing factor of car-diovascular disease .Cardiovascular disease is a leading cause of morbidity and mortality all over the world. Studies have shown that subjects having pre-diabetes are also at a high risk for CVD. Pre-diabetesrefers to an intermediatestage between normal glucose toleranceand overt T2DM, Glycated albumin reflects short-term (2-3 weeks) mean glycemic levels. GA val-ues, unlike HbAlc, are not affected by changes in erythrocyte lifespan. Aim of Study: The aim of the study is to correlate between HbAlc, glycated albumin and cardiovascular risk factors in prediabetic metabolic syndrome patients. Patients and Methods: One hundred pre-diabetic patients diagnosed as metabolic syndrome were subjected to full histo-ry taking and examination, full anthropometric measurements, laboratory tests including: FBS, uric acid, HbAlc, lipid profile, glycated albumin levels, urea, creatinine and A/c ratio. Results:Our study showed that anthropometric measures including weight, waist circumference, neck circumference, hip circumference, triceps thicknesswere all negatively corre-lated to glycated albuminwith p-values (<0.001, 0.003, <0.001, 0.007, 0.014) respectively. On the other hand weight, waist circumference, neck circumference and subscapular skin fold thickness were positively correlated to HbAlc level with p-val-ues (<0.001, 0.01, 0.016 and 0.009) respectively. Regarding metabolic syndrome and cardiovascular risk factors, Triglyceride levels are negatively correlated to HbAlc levels (p-value 0.01). LDL levels are positively correlated to HbAlc levels (p-value 0.02). BMI is negatively correlated to glycated albumin level (p-value <0.001) but positively correlat-ed to HbAlc level (p-value <0.001). As for pre-diabetes, fasting blood sugar is positively correlated to glycated albumin levels (p-value 0.002) with no statistical correlation to HbAlc levels. Conclusion: Both glycated albumin and HBA1c are cor-related to anthropometric measures hence their importance in assessment of obesity. HbAlc is more correlated to metabolic syndrome and cardiovascular risk factors than glycated albu-min. Glycated albumin showed positive correlation to FBG, thus can be used for diagnosis of pre-diabetes especially when combined with HbAlc. | ||||
| Keywords | ||||
| Metabolic syndrome — HbAl c — Glycated albumin — Cardiovascular risk factors — Pre; diabetes | ||||
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