Impact of Essential Oils (Orange Peels) on Ehrlich Ascites Carcinoma Against Cardiac Damage in Female Mice | ||||
| Journal of Medical and Life Science | ||||
| Volume 6, Issue 1, March 2024, Page 41-50 PDF (1.35 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmals.2024.266129.1018 | ||||
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| Authors | ||||
Ahmed Flayyih Hasan   1; Haneen Mushtaq Hameed1; Mohanad Salam Hussein2; Alaa Saadi Abbood3; Assala Arkan Jawad4; Marwa mohammed mahmoud Nada5
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| 1Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq. | ||||
| 2National Center of Hematology, Mustansiriyah University, Baghdad, Iraq.. | ||||
| 3Iraqi center for cancer and medical genetics research/Mustansiriyah University, Iraq | ||||
| 4Department of Biology, Al-Farabi University College, Baghdad, Iraq. | ||||
| 5Pathology Department - Animal Health Research Institute, Iraq | ||||
| Abstract | ||||
| Cancer is defined as the accumulation of abnormal cells that are formed by cell proliferation and cause damage to all organs. According to reports from the World Health Organization, the number of people infected with this disease exceeds ten million, Essential oils are a blend of several non-terpenoid chemicals that are beneficial in food flavoring, medications, and cosmetics. This study focused on studying the preventive role of essential oils as a treatment for cancer. This study's goal was to ascertain the effects of Essential oils (orange peels) against Ehrlich Ascites Carcinoma-induced cardiac toxicity. 40 mice were divided into four groups at random (G1, control; G2, Essential oils (orange peels) (25 mg/kg bw/day) orally for 2 weeks; G3, EAC and G4, EAC + Essential oils (orange peels)). Current findings showed, that EAC induced a significant elevation in creatine kinase myoglobin (CK-MB), cholesterol, triglycerides, potassium, and sodium, a significant increase in serum AFP, CEA, and Desmine expressions when compared to Essential oils (orange peels), and control groups. EAC + Essential oils (orange peels) adjust these modifications. EAC-induced cardiac dysfunction and Essential oils (orange peels) can improve cardiac functions, and post-treated EAC with Essential oils (orange peels) improved, AFP and CEA Levels and Desmine expressions. It is possible to utilize essential oils (orange peels) as a supportive treatment for cardiac ascites caused by hepatocellular carcinoma, Schistosoma, and hepatitis. | ||||
| Keywords | ||||
| EAC; Essential Oils (Orange Peels). Cardiac Functions; AFP; CEA; electrolytes | ||||
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