Evaluation of Xylazine Ketamine Anesthesia in Rabbits Undergoing Tendon Surgery: A Prospective Randomized Controlled Study | ||||
| New Valley Veterinary Journal | ||||
| Volume 4, Issue 1, January 2024 PDF (1.54 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/nvvj.2023.247402.1038 | ||||
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| Authors | ||||
Mahmoud Atiya Hassan  1; Mohamed Abd Elkawi2; Mahmoud S Saber2; Waleed Senosy 3; Mahmoud Nassif4; Mohamed Wefky ElSherif 5
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| 1Department of surgery, anesthesiology and radiology , Faculty of veterinary medicine, New Valley University | ||||
| 2Department of surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, New Valley University, 22751, El-Kharga, New Valley, Egypt. | ||||
| 3Theriogenology Department, Faculty of Veterinary Medicine, New Valley University, Al Kharga, New Valley | ||||
| 4Department of surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Assiut University, Egypt. | ||||
| 5Department of Surgery, Faculty of Veterinary Medicine, New Valley University, Egypt. | ||||
| Abstract | ||||
| This study was designed to evaluate the effects of xylazine-ketamine anesthesia on reflexes and vital signs during and after tendon surgery in rabbits. Twenty healthy adult male rabbits (2-2.5 kg) were randomly assigned to two groups XK (Xylazine-ketamine) and K (ketamine). Intramuscular injections of xylazine (5 mg/kg) and ketamine (35 mg/kg), were given to rabbits. Clinical parameters (rectal temperature, heart rate, and respiratory rate) were estimated prior to injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 minutes post-anesthetic injection, as well as reflexes (ear pinch reflex, and pedal reflex), were measured before and after anesthetic injection. In the XK group, we observed that rectal temperature increased considerably (P<0.05) at 5 and 15 minutes after induction and then gradually fell to preanesthetic control values. During the anesthetic phase, both groups' heart rates and respiration rates reduced significantly. In XK-injected rabbits, the return of reflexes was delayed. Surgical anesthesia lasted much longer in the animals of XK groups. The XK combination provided sufficient anesthesia for rabbits, as evidenced by a prolonged anesthetic period, and good cardiovascular and other clinical indices | ||||
| Keywords | ||||
| Anesthesia; Ketamine; Rabbit; Tendon; Xylazine | ||||
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