Clinicopathological Impact of CPA4, UHRF1, Glypican-1, and CD90 Expression in Lung Adenocarcinoma and Epithelioid Malignant Mesothelioma | ||||
| Zagazig University Medical Journal | ||||
| Article 41, Volume 30, Issue 3, May and June 2024, Page 978-991 PDF (1.57 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.270576.3175 | ||||
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| Authors | ||||
Doaa I. Abdelrahman1; Mariem A. Elfeky2; Marwa M. El Mosely  3; Doaa Mandour4; Mohamed M. Abozaid5; Rehab Hemeda6
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| 1Lecturer of Pathology, Zagazig University, Zagazig, Egypt | ||||
| 2associate professor of pathology, Zagazig university, Egypt. | ||||
| 3Lecturer of Pathology, Zagazig University, Egypt | ||||
| 4associate professor of Clinical oncology and Nuclear Medicine, Zagazig University, Egypt | ||||
| 5associate professor of Chest, Zagazig University, Egypt | ||||
| 6associate professor of clinical oncology and nuclear medicine, faculty of medicine, Zagazig university, Egypt | ||||
| Abstract | ||||
| background: Accurate diagnosis, early detection, and differentiation of lung adenocarcinoma from mesothelioma; particularly the epithelioid subtype is needed to allow better management thus to improve their prognosis. Aim of our study was to assess applicability of CPA4, UHRF1, glypican-1 and CD90 expression by immunohistochemistry to differentiate between lung adenocarcinoma and epithelioid mesothelioma in addition to detection of their prognostic roles and relation to patients’ survival. Methods: We collected samples from 30 patients diagnosed with lung adenocarcinoma and 30 patients diagnosed with epithelioid mesothelioma. For the immunohistochemistry, sections of all collected samples were incubated with CPA4, UHRF1, glypican-1 and CD90 to assess their diagnostic accuracy. RESULTS: A highly significant association was detected between positive CPA4, UHRF1 expression in lung adenocarcinoma and their diagnostic accuracy (p value <0.001). Also, highly significant association was detected between positive CD90, Glypican 1 expression in epithelioid mesothelioma and their diagnostic accuracy (p value <0.001). CPA4 expression was associated with shorter OS rate (P value 0.019, 0.009) UHRF1 expression was associated with shorter OS rate (P value=0.009) Conclusions: CPA4, UHRF1, glypican-1 and CD90 were considered novel biomarkers that have important roles in differentiation between epithelioid malignant mesothelioma and adenocarcinoma of the lung with high sensitivity and specificity. | ||||
| Keywords | ||||
| lung Adenocarcinoma; CPA4; UHRF1; Glypican-1; CD90 | ||||
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