FACIAL APPROACH FOR THE SYNTHESIS OF ZINC OXIDE/ BOSWELLIA GUM RESIN NANOPARTICLES | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 03 March 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.262118.9174 | ||||
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| Authors | ||||
Mervat Magdy Shahen  1; Nadia Mohammed Ahmed2; Emad Tolba 3; Omali Youssef El-Khawaga 1
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| 1Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt | ||||
| 2Medical Biochemistry Dept, Medical researches and clinic studies institute, Dokki, Cairo, 12311, Egypt | ||||
| 3Polymers and Pigments Department, National Research Centre, 33 El Bohouth St, Dokki, Cairo, 12311, Egypt | ||||
| Abstract | ||||
| Research on the synthesis of multifunctional metal-based nanoparticles using natural extracts is expanding quickly in the biomedical field. Zinc oxide nanoparticles (ZnO-NPs) are well-known bioactive inorganic nanoparticles that have been extensively investigated in regenerative medicine. Herein, ZnO-NPs were prepared using water soluble zinc chloride salt with sodium hydroxide in the presence of Triethanolamine (TEA), as a surfactant agent. ZnO-NPs were functionalized with the Oleo gum resin (BSE) using an in-situ loading approach. The morphology and structure of the as-prepared materials were characterized using TEM, XRD, and Ȥ-potential & DLS. In addition, the cell viability of normal human skin fibroblasts (HSF) after its exposure to varying concentrations of the as-prepared ZnO-NPs and BSE-loaded ZnO-NPs. Although, the XRD data indicates the formation of Zincite phase in the presence/absence of BSE. The TEM results show that ZnO-NPs changed from a rod-like structure with an average particle size 172±29nm in width and 40±12nm in length to an irregular spherical NPs with an average particle size 49±8nm for 10BSE-ZnO-NPs and 15±3nm for 20BSE-ZnO-NPs. The MTT test proves that 20BSE-ZnO-NPs enhance cell growth and show reduced toxicity against HSF cells compared to 10BSE-ZnO-NPs. the obtained results suggest that the ZNO-NPs containing BSE provide a better stimulatory response against Human fibroblast cells, which confirm that the BSE loaded-ZnO-NPs may be utilized in skin tissue healing application. | ||||
| Keywords | ||||
| Zinc oxide nanoparticles (ZnO-NPs); green synthesis; glycerol; Triethanolamine (TEA); Oleo gum resin (BSE); characterization; cytotoxicity | ||||
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