Diagnostic Value of High b-Values Diffusion Weighted Magnetic Resonance imaging (DW-MRI) in Differentiating Solid Breast Masses
AbdelHamid, G., Abo Shofa, F., zaiton, F., khattab, E., Darwish, Z., Alshamy, A. (2025). Diagnostic Value of High b-Values Diffusion Weighted Magnetic Resonance imaging (DW-MRI) in Differentiating Solid Breast Masses. EKB Journal Management System, 31(1.1), 104-119. doi: 10.21608/zumj.2024.273858.3218
Ghada Adel AbdelHamid; Fowzia Ahmed Abo Shofa; Fatma Mahmoued zaiton; Enas khattab; Zidan Darwish; Asmaa Abdallah Alshamy. "Diagnostic Value of High b-Values Diffusion Weighted Magnetic Resonance imaging (DW-MRI) in Differentiating Solid Breast Masses". EKB Journal Management System, 31, 1.1, 2025, 104-119. doi: 10.21608/zumj.2024.273858.3218
AbdelHamid, G., Abo Shofa, F., zaiton, F., khattab, E., Darwish, Z., Alshamy, A. (2025). 'Diagnostic Value of High b-Values Diffusion Weighted Magnetic Resonance imaging (DW-MRI) in Differentiating Solid Breast Masses', EKB Journal Management System, 31(1.1), pp. 104-119. doi: 10.21608/zumj.2024.273858.3218
AbdelHamid, G., Abo Shofa, F., zaiton, F., khattab, E., Darwish, Z., Alshamy, A. Diagnostic Value of High b-Values Diffusion Weighted Magnetic Resonance imaging (DW-MRI) in Differentiating Solid Breast Masses. EKB Journal Management System, 2025; 31(1.1): 104-119. doi: 10.21608/zumj.2024.273858.3218

Diagnostic Value of High b-Values Diffusion Weighted Magnetic Resonance imaging (DW-MRI) in Differentiating Solid Breast Masses

Zagazig University Medical Journal
Article 13, Volume 31, Issue 1.1, January 2025, Page 104-119  XML PDF (1.18 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2024.273858.3218
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Authors
Ghada Adel AbdelHamid email 1; Fowzia Ahmed Abo Shofa2; Fatma Mahmoued zaitonorcid 3; Enas khattab3; Zidan Darwish4; Asmaa Abdallah Alshamy5
1Radiodiagnosis Department , Faculty of Medicine , Zagazig ,Egypt
2- M.B.B.CH, Faculty of Medicine, Sirte University, Libya
3Radiodiagnosis Department, Faculty of Medicine, Zagazig, Egypt
4Faculty of Medicine, Cairo University, Egypt
5Radiodiagnosis Department, Faculty of Medicine, Zagazig , Egypt
Abstract
Abstract:

Background & Objectives: Diffusion-weighted imaging (DWI) is worldwide integrated in the routine breast MRI protocols. We aim to estimate the diagnostic accuracy of DWI with high b-values in diagnosis of breast masses in comparison with dynamic contrast-enhanced MRI (CE-MRI).

Patients & Methods: This study included 42 female patients with breast masses detected by mammography or ultrasonography. All patients were subjected to MRI breast examination including unenhanced MRI (UE-MRI) sequences, DWI with different high b-values (1000, 1200, 1500 & 1800) and CE-MRI. The obtained images were evaluated with particular emphasis on the pattern of lesion visibility and image quality of DWI at different high b values. Final diagnosis was acquired by histopathological evaluation or follow-up.

Results: Recorded sensitivity for DWI in differentiating benign and malignant masses was the same for b 1000, 1200 & 1500 estimating 92.9%, the specificity 61.9%, the positive predictive value (PPV) 77.8%, the negative predictive value ( NPV) 85.8% and accuracy 80.2%. The validity of DWI seems to decrease with increasing b value above 1500 and measuring 89.3%, 47.6 %, 72.2%, 71 % and 75.5 % for sensitivity, specificity, accuracy, PPV & NPV respectively at b 1800. The measured ADC value differentiating benign and malignant lesions was found to be statistically highly significant (P value < 0.001).

Conclusion: DWI-MRI utilizing high b-values is a beneficial tool in breast lesion diagnosis. DWI with 1200–1500 s/mm2 b-values can improve breast tumor detectability than with b value =1800, but this does not significantly affect the DWI diagnostic performance.
Keywords
Keywords: DWI; high b values; ADC; Breast masses; MRI
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