Ameliorative Effect of Cinnamon against Hypercholesterolemia Induced by High-Fat Diet in The Adult Male Albino Rat's Adrenal Gland; Histological, Ultrastructural, and Immunohistochemical Studies | ||||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||||
| Volume 16, Issue 1, June 2024, Page 47-64 PDF (2.24 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsz.2024.344611 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Eman H. Kandil1; Samah M. Arisha1; Mona E. Saif2 | ||||
| 1Zoology Department, Faculty of Science, Menoufia University, Shebin EI-Kom 32551, Egypt. | ||||
| 2Histology Department, Egyptian Drug Authority. | ||||
| Abstract | ||||
| Obesity is a global health issue of great concern. It leads to hyperplasia, hypertrophy of adipocytes, and metabolic complications including coronary artery disease, and cerebrovascular disease. The effectiveness of cinnamon zeylanicum as a medicinal herb comes from its anti-inflammatory and antioxidant properties. The purpose of this study was to assess the potential beneficial effects of cinnamon on adrenal toxicity caused by a high-fat diet in male albino rats. Four equal groups of the experimental animals were used, the control group, the cinnamon group, the high-fat diet group, the high-fat diet, and the cinnamon group. Animals fed cinnamon showed similar results with the control group. The adrenal cortex sections of high-fat diet-fed animals showed different degenerative changes in all layers of the adrenal gland, cortex, medulla, and corrugation of the capsule. Ultra structurally, a lot of adrenal cortical cells appeared with irregular pyknotic nuclei, swollen mitochondria, dilated sER, and numerous lipid droplets with variable shapes and sizes. Moreover, a significant rise in the immunohistochemical expression of cytochrome c in a large number of cortical cells was observed. On the contrary, animals given cinnamon and a high-fat diet exhibited noticeable improvement in the structure of the adrenal gland, and the immunohistochemical expression of cytochrome c was observed in the third group. The histological structure of the adrenal gland appeared to be mostly the same as the control one. Cinnamon has a potential effect in improving adrenal toxicity against a high-fat diet because of the natural constituent capable of its pharmaceutical effects. | ||||
| Keywords | ||||
| Adrenal gland; cinnamon; histology; ultrastructure; cytochrome c | ||||
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