Chronic granulomatous disease in Sohag university hospital: Case series | ||||
| Sohag Medical Journal | ||||
| Article 6, Volume 22, Issue 2, July 2018, Page 41-43 PDF (34.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2018.34480 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Eman Mohamed Fahmy | ||||
| Department of pediatric ,Faculty of Medicine, Sohag university. | ||||
| Abstract | ||||
| Introduction: Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency disorder with an incidence of 4-5 per 1 million individuals.It is caused by mutation in 5 genes, CYBA, CYBB, NCF1, NCF2, or NCF4 genes, CYBB inherited as X-linked while other 4genes inherited as autosomal recessive. CGD is characterized by neutrophils and monocytes capable of normal chemotaxis, ingestion and degranulation, but unable to kill catalase-positive microorganisms due to defects in one of the 5 major subunits of NADPH oxidase. Method: The medical records ofpatients diagnosed withCGD within 1 year from August 2017 toJuly 2018 were reviewed and analyzed with respect to demographic data, age atpresentation and diagnosis, clinical features, laboratory investigations, organisms isolated and treatment &prophylaxis given. Aim: Increase awareness of pediatric physiciansin sohag government aboutCGD for early diagnosis and early management. Results: 15 patients were diagnosed with CGD in the period of the study with failure to thrive and lymphadenopathywere the common presentation of them. | ||||
| References | ||||
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