SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 4, Volume 31, Issue 2, December 2008, Page 197-214 PDF (554.5 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2008.345095 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Safinaz E. S. Abbas; Hanan H. Georgey; Shimaa M. Abdelrahman; Gamil M. El-Taliawi | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt | ||||
| Abstract | ||||
| The synthesis of twenty nine novel derivatives of pyrazolo[3,4-d]pyrimidines as non acidic nonsteroidal anti-inflammatory drugs has been achieved via reaction of 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine with different substituents including 4-amino-3-methylphenol, 4-phenylene diamine and 4-acetamidophenol.The anti-inflammatory activity of thirteen representative compounds have been screened compared to indomethacin as a reference drug. The results revealed that all the tested compounds showed anti-inflammatory activity with the exception of 10a. | ||||
|
Statistics Article View: 12 PDF Download: 10 |
||||
